Safety evaluation of oral toxicity of Carica papaya Linn. Leaves

A subchronic toxicity study in Sprague Dawley rats

Zakiah Ismail, Siti Zaleha Halim, Noor Rain Abdullah, Adlin Afzan, Badrul Amini Abdul Rashid, Ibrahim Jantan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The subchronic toxicity effect of the leaf extract of Carica papaya Linn. in Sprague Dawley (SD) rats was investigated in this study. The extract was prepared by dissolving the freeze dried extract of the leaves in distilled water and was administered orally to SD rats (consisted of 10 rats/sex/group) at 0 (control), 0.01, 0.14, and 2 g/kg body weight (BW) for 13 weeks. General observation, mortality, and food and water intake were monitored throughout the experimental period. Hematological and biochemical parameters, relative organ weights, and histopathological changes were evaluated. The study showed that leaf extract when administered for 13 weeks did not cause any mortality and abnormalities of behavior or changes in body weight as well as food and water intake. There were no significant differences observed in hematology parameters between treatment and control groups; however significant differences were seen in biochemistry values, for example, LDH, creatinine, total protein, and albumin. However, these changes were not associated with histopathological changes. In conclusion, the results suggested that daily oral administration of rats with C. papaya leaf extract for 13 weeks at a dose up to fourteen times the levels employed in traditional medicine practice did not cause any significant toxic effect.

Original languageEnglish
Article number741470
JournalEvidence-based Complementary and Alternative Medicine
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Carica
Drinking
Sprague Dawley Rats
Eating
Safety
Body Weight Changes
Organ Size
Mortality
Poisons
Traditional Medicine
Hematology
Biochemistry
Oral Administration
Albumins
Creatinine
Body Weight
Observation
Control Groups
Water
Proteins

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Safety evaluation of oral toxicity of Carica papaya Linn. Leaves : A subchronic toxicity study in Sprague Dawley rats. / Ismail, Zakiah; Halim, Siti Zaleha; Abdullah, Noor Rain; Afzan, Adlin; Abdul Rashid, Badrul Amini; Jantan, Ibrahim.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2014, 741470, 2014.

Research output: Contribution to journalArticle

Ismail, Zakiah ; Halim, Siti Zaleha ; Abdullah, Noor Rain ; Afzan, Adlin ; Abdul Rashid, Badrul Amini ; Jantan, Ibrahim. / Safety evaluation of oral toxicity of Carica papaya Linn. Leaves : A subchronic toxicity study in Sprague Dawley rats. In: Evidence-based Complementary and Alternative Medicine. 2014 ; Vol. 2014.
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