Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction

Lislivia Yiang Nee Si, Siti Aishah Mohd Ali, Jalifah Latip, Norsyahida Mohd Fauzi, Siti Balkis Budin, Satirah Zainalabidin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aims Obesity increase the risks of hypertension and myocardial infarction (MI) mediated by oxidative stress. This study was undertaken to investigate the actions of roselle aqueous extract (R) on cardiotoxicity in obese (OB) rats and thereon OB rats subjected to MI. Main methods Male Sprague-Dawley rats were fed with either normal diet or high-fat diet for 8 weeks. Firstly, OB rats were divided into (1) OB and (2) OB + R (100 mg/kg, p.o, 28 days). Then, OB rats were subjected to MI (ISO, 85 mg/kg, s.c, 2 days) and divided into three groups: (1) OB + MI, (2) OB + MI + R and (3) OB + MI + enalapril for another 4 weeks. Key findings Roselle ameliorated OB and OB + MI's cardiac systolic dysfunction and reduced cardiac hypertrophy and fibrosis. The increased oxidative markers and decreased antioxidant enzymes in OB and OB + MI groups were all attenuated by roselle. Significance These observations indicate the protective effect of roselle on cardiac dysfunction in OB and OB + MI rats, which suggest its potential to be developed as a nutraceutical product for obese and obese patients with MI in the future.

Original languageEnglish
Pages (from-to)157-165
Number of pages9
JournalLife Sciences
Volume191
DOIs
Publication statusPublished - 15 Dec 2017

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Hibiscus
Nutrition
Rats
Obesity
Myocardial Infarction
Diet
Enalapril
Oxidative stress
Antioxidants
Fats
Cardiomegaly
High Fat Diet
Dietary Supplements
Sprague Dawley Rats
Oxidative Stress
Fibrosis
Enzymes
Hypertension

Keywords

  • Cardiac function
  • Myocardial infarction
  • Obesity
  • Oxidative stress
  • Roselle

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction. / Si, Lislivia Yiang Nee; Ali, Siti Aishah Mohd; Latip, Jalifah; Mohd Fauzi, Norsyahida; Budin, Siti Balkis; Zainalabidin, Satirah.

In: Life Sciences, Vol. 191, 15.12.2017, p. 157-165.

Research output: Contribution to journalArticle

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