RORA gene rs12912233 and rs880626 polymorphisms and their interaction with SCN1A rs3812718 in the risk of epilepsy: A case-control study in Malaysia

Batoul Sadat Haerian, Hidayati Mohd Sha'ari, Hui Jan Tan, Choong Yi Fong, Sau Wei Wong, Lai Choo Ong, Raymond Azman Ali, Chong Tin Tan, Zahurin Mohamed

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

RAR-related orphan receptors A (RORA) and B (RORB) and voltage-gated sodium channel type 1 (SCN1A) genes play critical roles in the regulation of the circadian clock. Evidence has shown an association of RORA and RORB polymorphisms with susceptibility to autism and depression. Hence, we tested the association of RORA rs12912233, rs16943429, rs880626, rs2290430, and rs12900948; RORB rs1157358, rs7022435, rs3750420, and rs3903529; and SCN1A rs3812718 with epilepsy risk in the Malaysians. DNA was genotyped in 1789 subjects (39% epilepsy patients) by using MassARRAY (Sequenom). Significant association was obtained for rs12912233 in Malaysian Chinese (p= 0.003). Interaction between rs12912233-rs880626 and rs3812718 was associated with the epilepsy risk in the subjects overall (p= 0.001). Results show that RORA rs12912233 alone might be a possible risk variant for epilepsy in Malaysian Chinese, but that, together with RORA rs880626 and SCN1A rs3812718, this polymorphism may have a synergistic effect in the epilepsy risk in Malaysians.

Original languageEnglish
Pages (from-to)229-236
Number of pages8
JournalGenomics
Volume105
Issue number4
DOIs
Publication statusPublished - 1 Apr 2015

Fingerprint

Orphaned Children
Malaysia
Case-Control Studies
Epilepsy
Genes
Nuclear Receptor Subfamily 1, Group F, Member 2
Nuclear Receptor Subfamily 1, Group F, Member 1
NAV1.1 Voltage-Gated Sodium Channel
Circadian Clocks
Autistic Disorder
Depression
DNA

Keywords

  • Epilepsy
  • Polymorphism
  • RORA
  • RORB
  • SCN1A
  • Susceptibility

ASJC Scopus subject areas

  • Genetics

Cite this

RORA gene rs12912233 and rs880626 polymorphisms and their interaction with SCN1A rs3812718 in the risk of epilepsy : A case-control study in Malaysia. / Haerian, Batoul Sadat; Sha'ari, Hidayati Mohd; Tan, Hui Jan; Fong, Choong Yi; Wong, Sau Wei; Ong, Lai Choo; Ali, Raymond Azman; Tan, Chong Tin; Mohamed, Zahurin.

In: Genomics, Vol. 105, No. 4, 01.04.2015, p. 229-236.

Research output: Contribution to journalArticle

Haerian, Batoul Sadat ; Sha'ari, Hidayati Mohd ; Tan, Hui Jan ; Fong, Choong Yi ; Wong, Sau Wei ; Ong, Lai Choo ; Ali, Raymond Azman ; Tan, Chong Tin ; Mohamed, Zahurin. / RORA gene rs12912233 and rs880626 polymorphisms and their interaction with SCN1A rs3812718 in the risk of epilepsy : A case-control study in Malaysia. In: Genomics. 2015 ; Vol. 105, No. 4. pp. 229-236.
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