Role of the placental Vitamin D receptor in modulating feto-placental growth in fetal growth restriction and preeclampsia-affected pregnancies

Padma Murthi, Hannah E J Yong, Thy P H Ngyuen, Stacey Ellery, Harmeet Singh, Rahana Abd Rahman, Hayley Dickinson, David W. Walker, Miranda Davies-Tuck, Euan M. Wallace, Peter R. Ebeling

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Fetal growth restriction (FGR) is a common pregnancy complication that affects up to 5% of pregnancies worldwide. Recent studies demonstrate that Vitamin D deficiency is implicated in reduced fetal growth, which may be rescued by supplementation of Vitamin D. Despite this, the pathway(s) by which Vitamin D modulate fetal growth remains to be investigated. Our own studies demonstrate that the Vitamin D receptor (VDR) is significantly decreased in placentae from human pregnancies complicated by FGR and contributes to abnormal placental trophoblast apoptosis and differentiation and regulation of cell-cycle genes in vitro. Thus, Vitamin D signaling is important for normal placental function and fetal growth. This review discusses the association of Vitamin D with fetal growth, the function of Vitamin D and its receptor in pregnancy, as well as the functional significance of a placental source of Vitamin D in FGR. Additionally, we propose that for Vitamin D to be clinically effective to prevent and manage FGR, the molecular mechanisms of Vitamin D and its receptor in modulating fetal growth requires further investigation.

Original languageEnglish
Article number43
JournalFrontiers in Physiology
Volume7
Issue numberFEB
DOIs
Publication statusPublished - 18 Feb 2016
Externally publishedYes

Fingerprint

Calcitriol Receptors
Fetal Development
Pre-Eclampsia
Vitamin D
Pregnancy
Growth
cdc Genes
Vitamin D Deficiency
Pregnancy Complications
Trophoblasts
Placenta
Apoptosis

Keywords

  • Fetal growth restriction
  • Placental transport
  • Trophoblast
  • VDR

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Role of the placental Vitamin D receptor in modulating feto-placental growth in fetal growth restriction and preeclampsia-affected pregnancies. / Murthi, Padma; Yong, Hannah E J; Ngyuen, Thy P H; Ellery, Stacey; Singh, Harmeet; Abd Rahman, Rahana; Dickinson, Hayley; Walker, David W.; Davies-Tuck, Miranda; Wallace, Euan M.; Ebeling, Peter R.

In: Frontiers in Physiology, Vol. 7, No. FEB, 43, 18.02.2016.

Research output: Contribution to journalReview article

Murthi, P, Yong, HEJ, Ngyuen, TPH, Ellery, S, Singh, H, Abd Rahman, R, Dickinson, H, Walker, DW, Davies-Tuck, M, Wallace, EM & Ebeling, PR 2016, 'Role of the placental Vitamin D receptor in modulating feto-placental growth in fetal growth restriction and preeclampsia-affected pregnancies', Frontiers in Physiology, vol. 7, no. FEB, 43. https://doi.org/10.3389/fphys.2016.00043
Murthi, Padma ; Yong, Hannah E J ; Ngyuen, Thy P H ; Ellery, Stacey ; Singh, Harmeet ; Abd Rahman, Rahana ; Dickinson, Hayley ; Walker, David W. ; Davies-Tuck, Miranda ; Wallace, Euan M. ; Ebeling, Peter R. / Role of the placental Vitamin D receptor in modulating feto-placental growth in fetal growth restriction and preeclampsia-affected pregnancies. In: Frontiers in Physiology. 2016 ; Vol. 7, No. FEB.
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