Role of probiotics in modulating glucose homeostasis: Evidence from animal and human studies

Somayyeh Firouzi, Mohd Y. Barakatun-Nisak, Amin Ismail, Hazreen Abdul Majid, Nor Azmi Kamaruddin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aim: Evidences from several studies suggest that probiotics affect glucose homeostasis. This paper reviews the results of animal and human studies on the role of probiotics in modulating glucose homeostasis. Method: A systematic literature search using multiple databases was conducted without time limitation. Primary outcomes evaluated were parameters related to glucose homeostasis. Secondary outcomes were inflammatory markers, lipid profile, body weight, and energy intake. Results: A total of 17 animal studies and four human studies were identified. Among these, 16 animal studies and three human studies had documented significant improvements in at least one glucose homeostasis related parameter. Inflammatory markers and lipid profile were significantly improved in the animal model, while data from human studies were controversial. Changes in body weight and energy intake that could be due to probiotics supplementation were also inconclusive. Conclusion: Well-designed placebo-controlled clinical trials with validated outcome variables are needed to determine the effect of probiotics on glucose homeostasis.

Original languageEnglish
Pages (from-to)780-786
Number of pages7
JournalInternational Journal of Food Sciences and Nutrition
Volume64
Issue number6
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Probiotics
probiotics
homeostasis
Homeostasis
Glucose
glucose
animals
Energy Intake
energy intake
Lipids
Body Weight Changes
body weight changes
Controlled Clinical Trials
lipids
placebos
clinical trials
Animal Models
animal models
Placebos
Body Weight

Keywords

  • Bifidobacterium
  • Diabetes
  • Glucose homeostasis
  • Lactobacillus
  • Probiotics

ASJC Scopus subject areas

  • Food Science

Cite this

Role of probiotics in modulating glucose homeostasis : Evidence from animal and human studies. / Firouzi, Somayyeh; Barakatun-Nisak, Mohd Y.; Ismail, Amin; Majid, Hazreen Abdul; Kamaruddin, Nor Azmi.

In: International Journal of Food Sciences and Nutrition, Vol. 64, No. 6, 09.2013, p. 780-786.

Research output: Contribution to journalArticle

Firouzi, Somayyeh ; Barakatun-Nisak, Mohd Y. ; Ismail, Amin ; Majid, Hazreen Abdul ; Kamaruddin, Nor Azmi. / Role of probiotics in modulating glucose homeostasis : Evidence from animal and human studies. In: International Journal of Food Sciences and Nutrition. 2013 ; Vol. 64, No. 6. pp. 780-786.
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