Role of phIGFBP-1 and ultrasound cervical length in predicting pre-term labour

Nor Azlin Mohamed Ismail, H. Kee Bang, L. Joe An, Mohamad Nasir Shafiee, N. A. Mansor, B. See Yee, N. H. Zulkifli, Azmi Mohd. Tamil

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This prospective observational study was to evaluate the efficacy of combining phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) and transvaginal ultrasound cervical length (CL) compared with either indicator alone in predicting pre-term labour (PTL). Women with singleton pregnancy between 24 and 36 weeks' gestation with evidence of PTL were subjected to phIGFBP-1 and CL tests. Of the 51 women, five were tested positive (phIGFBP-1 positive and CL<2.5cm) for combination of phIGFBP-1 and CL (four delivered within 1 week), whereas 46 tested negative, of which, only one delivered. A much higher negative predictivity (NP), positive predictivity (PP) and specificity (SP) in the combination test was seen compared with phIGFBP-1 or CL alone (NP: 97.8% vs 97.7% vs 97.1%; PP: 80.0% vs 51.1% and CL 23.5%; SP: 97.8% vs 93.5% vs 71.1%, respectively). The cervical os dilatation of 2cm with combined positive test (p=0.001) indicated a higher likelihood of PTL.

Original languageEnglish
Pages (from-to)456-460
Number of pages5
JournalJournal of Obstetrics and Gynaecology
Volume30
Issue number5
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Insulin-Like Growth Factor Binding Protein 1
First Labor Stage
Pregnancy
Observational Studies
Prospective Studies

Keywords

  • Cervical length
  • Combination
  • IGFBP-1
  • Pre-term labour
  • Ultrasound

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Role of phIGFBP-1 and ultrasound cervical length in predicting pre-term labour. / Mohamed Ismail, Nor Azlin; Bang, H. Kee; An, L. Joe; Shafiee, Mohamad Nasir; Mansor, N. A.; Yee, B. See; Zulkifli, N. H.; Mohd. Tamil, Azmi.

In: Journal of Obstetrics and Gynaecology, Vol. 30, No. 5, 07.2010, p. 456-460.

Research output: Contribution to journalArticle

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