Role of panendoscopy and biopsy in cervical lymph node metastasis with unknown primary: A tertiary center experience

Azlan Iskandar Ishak, Mohd. Razif Mohamad Yunus, Mazita Ami, Primuharsa Putra

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective To evaluate the role of panendoscopy and biopsy in diagnosing occult primary site of cancer in the head and neck region. Methods A retrospective review of patient clinical notes, radiological, histological and intra-operative reports who underwent panendoscopy and biopsy of the upper aerodigestive tract. Results Out of 11 patients, six had undifferentiated carcinoma and five had squamous cell carcinoma (SCC) of the cervical lymph nodes. Nine underwent CT scan of the head and neck and one had a positron emission tomography scan. One patient had no radiological imaging. None of these studies were able to locate a primary tumor. Random biopsies from sites of possible origin of the primary tumor with tonsillectomies confirmed the primary site in 10 patients; three had nasopharyngeal carcinoma, four had SCC of the tonsils with three patients with unilateral and one with bilateral involvement, one each with SCC of the base of tongue, SCC of both vocal cord and non Hodgkin's lymphoma of bilateral tonsils. In one patient, no site of origin of the primary tumor was identified in the head and neck region. Conclusion Panendoscopy and biopsies had significant role in arriving at a conclusive diagnosis as compared to imaging studies in cases of metastatic cervical lymph nodes with an occult primary.

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalRawal Medical Journal
Volume35
Issue number2
Publication statusPublished - Jul 2010

Fingerprint

Lymph Nodes
Neoplasm Metastasis
Biopsy
Squamous Cell Carcinoma
Palatine Tonsil
Neck
Head
Neoplasms
Tonsillectomy
Vocal Cords
Head and Neck Neoplasms
Tongue
Positron-Emission Tomography
Non-Hodgkin's Lymphoma
Carcinoma

Keywords

  • Aerodigestive tract
  • Head and neck cancer
  • Occult primary tumor
  • Panendoscopy

ASJC Scopus subject areas

  • Medicine(all)
  • Nursing(all)

Cite this

Role of panendoscopy and biopsy in cervical lymph node metastasis with unknown primary : A tertiary center experience. / Ishak, Azlan Iskandar; Mohamad Yunus, Mohd. Razif; Ami, Mazita; Putra, Primuharsa.

In: Rawal Medical Journal, Vol. 35, No. 2, 07.2010, p. 209-213.

Research output: Contribution to journalArticle

@article{ea600fd51c1945888a6999439db37a6d,
title = "Role of panendoscopy and biopsy in cervical lymph node metastasis with unknown primary: A tertiary center experience",
abstract = "Objective To evaluate the role of panendoscopy and biopsy in diagnosing occult primary site of cancer in the head and neck region. Methods A retrospective review of patient clinical notes, radiological, histological and intra-operative reports who underwent panendoscopy and biopsy of the upper aerodigestive tract. Results Out of 11 patients, six had undifferentiated carcinoma and five had squamous cell carcinoma (SCC) of the cervical lymph nodes. Nine underwent CT scan of the head and neck and one had a positron emission tomography scan. One patient had no radiological imaging. None of these studies were able to locate a primary tumor. Random biopsies from sites of possible origin of the primary tumor with tonsillectomies confirmed the primary site in 10 patients; three had nasopharyngeal carcinoma, four had SCC of the tonsils with three patients with unilateral and one with bilateral involvement, one each with SCC of the base of tongue, SCC of both vocal cord and non Hodgkin's lymphoma of bilateral tonsils. In one patient, no site of origin of the primary tumor was identified in the head and neck region. Conclusion Panendoscopy and biopsies had significant role in arriving at a conclusive diagnosis as compared to imaging studies in cases of metastatic cervical lymph nodes with an occult primary.",
keywords = "Aerodigestive tract, Head and neck cancer, Occult primary tumor, Panendoscopy",
author = "Ishak, {Azlan Iskandar} and {Mohamad Yunus}, {Mohd. Razif} and Mazita Ami and Primuharsa Putra",
year = "2010",
month = "7",
language = "English",
volume = "35",
pages = "209--213",
journal = "Rawal Medical Journal",
issn = "0303-5212",
publisher = "Pakistan Medical Association",
number = "2",

}

TY - JOUR

T1 - Role of panendoscopy and biopsy in cervical lymph node metastasis with unknown primary

T2 - A tertiary center experience

AU - Ishak, Azlan Iskandar

AU - Mohamad Yunus, Mohd. Razif

AU - Ami, Mazita

AU - Putra, Primuharsa

PY - 2010/7

Y1 - 2010/7

N2 - Objective To evaluate the role of panendoscopy and biopsy in diagnosing occult primary site of cancer in the head and neck region. Methods A retrospective review of patient clinical notes, radiological, histological and intra-operative reports who underwent panendoscopy and biopsy of the upper aerodigestive tract. Results Out of 11 patients, six had undifferentiated carcinoma and five had squamous cell carcinoma (SCC) of the cervical lymph nodes. Nine underwent CT scan of the head and neck and one had a positron emission tomography scan. One patient had no radiological imaging. None of these studies were able to locate a primary tumor. Random biopsies from sites of possible origin of the primary tumor with tonsillectomies confirmed the primary site in 10 patients; three had nasopharyngeal carcinoma, four had SCC of the tonsils with three patients with unilateral and one with bilateral involvement, one each with SCC of the base of tongue, SCC of both vocal cord and non Hodgkin's lymphoma of bilateral tonsils. In one patient, no site of origin of the primary tumor was identified in the head and neck region. Conclusion Panendoscopy and biopsies had significant role in arriving at a conclusive diagnosis as compared to imaging studies in cases of metastatic cervical lymph nodes with an occult primary.

AB - Objective To evaluate the role of panendoscopy and biopsy in diagnosing occult primary site of cancer in the head and neck region. Methods A retrospective review of patient clinical notes, radiological, histological and intra-operative reports who underwent panendoscopy and biopsy of the upper aerodigestive tract. Results Out of 11 patients, six had undifferentiated carcinoma and five had squamous cell carcinoma (SCC) of the cervical lymph nodes. Nine underwent CT scan of the head and neck and one had a positron emission tomography scan. One patient had no radiological imaging. None of these studies were able to locate a primary tumor. Random biopsies from sites of possible origin of the primary tumor with tonsillectomies confirmed the primary site in 10 patients; three had nasopharyngeal carcinoma, four had SCC of the tonsils with three patients with unilateral and one with bilateral involvement, one each with SCC of the base of tongue, SCC of both vocal cord and non Hodgkin's lymphoma of bilateral tonsils. In one patient, no site of origin of the primary tumor was identified in the head and neck region. Conclusion Panendoscopy and biopsies had significant role in arriving at a conclusive diagnosis as compared to imaging studies in cases of metastatic cervical lymph nodes with an occult primary.

KW - Aerodigestive tract

KW - Head and neck cancer

KW - Occult primary tumor

KW - Panendoscopy

UR - http://www.scopus.com/inward/record.url?scp=79951620507&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951620507&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:79951620507

VL - 35

SP - 209

EP - 213

JO - Rawal Medical Journal

JF - Rawal Medical Journal

SN - 0303-5212

IS - 2

ER -