Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia: Genes or environment?

Lai Fong Chan, Clement Zai, Marcellino Monda, Steven Potkin, James L. Kennedy, Gary Remington, Jeffrey Lieberman, Herbert Y. Meltzer, Vincenzo De Luca

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aim: This study explored the role of self-reported ethnicity and genetic ancestry on antipsychotic (AP)-induced weight gain and tardive dyskinesia (TD) in schizophrenia. Patients and methods: Ethnicity was determined by self-report as well as Structure analysis of 190 SNPs selected from HapMap3, genotyped using a customized Illumina BeadChip. Age, gender, baseline weight and AP response using Brief Psychiatric Rating Scale were assessed. Multivariate regression models for AP-induced weight gain and TD, based on the Abnormal Involuntary Movement Scale were constructed. Results: African-American ethnicity (self-report, p = 0.021 and Structure analysis, p = 0.042) predicted AP-induced weight gain but not TD (self-report, p = 0.408 and Structure analysis, p = 0.714). Conclusion: Self-reported African-American ethnicity seemed to better predict AP-induced weight gain in schizophrenia compared with genetic ancestry, suggesting a possible role of environmental in addition to genetic factors. Future larger studies are needed to clarify specific gene-environment mechanisms mediating the effect of ethnicity on AP-induced weight gain.

Original languageEnglish
Pages (from-to)1273-1281
Number of pages9
JournalPharmacogenomics
Volume14
Issue number11
DOIs
Publication statusPublished - 2013

Fingerprint

Antipsychotic Agents
Weight Gain
Self Report
Genes
African Americans
Schizophrenia
Brief Psychiatric Rating Scale
Single Nucleotide Polymorphism
Tardive Dyskinesia
Weights and Measures

Keywords

  • antipsychotic-induced weight gain
  • environment
  • genetics
  • schizophrenia
  • self-reported ethnicity
  • tardive dyskinesia

ASJC Scopus subject areas

  • Pharmacology
  • Genetics
  • Molecular Medicine
  • Medicine(all)

Cite this

Chan, L. F., Zai, C., Monda, M., Potkin, S., Kennedy, J. L., Remington, G., ... De Luca, V. (2013). Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia: Genes or environment? Pharmacogenomics, 14(11), 1273-1281. https://doi.org/10.2217/pgs.13.127

Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia : Genes or environment? / Chan, Lai Fong; Zai, Clement; Monda, Marcellino; Potkin, Steven; Kennedy, James L.; Remington, Gary; Lieberman, Jeffrey; Meltzer, Herbert Y.; De Luca, Vincenzo.

In: Pharmacogenomics, Vol. 14, No. 11, 2013, p. 1273-1281.

Research output: Contribution to journalArticle

Chan, LF, Zai, C, Monda, M, Potkin, S, Kennedy, JL, Remington, G, Lieberman, J, Meltzer, HY & De Luca, V 2013, 'Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia: Genes or environment?', Pharmacogenomics, vol. 14, no. 11, pp. 1273-1281. https://doi.org/10.2217/pgs.13.127
Chan, Lai Fong ; Zai, Clement ; Monda, Marcellino ; Potkin, Steven ; Kennedy, James L. ; Remington, Gary ; Lieberman, Jeffrey ; Meltzer, Herbert Y. ; De Luca, Vincenzo. / Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia : Genes or environment?. In: Pharmacogenomics. 2013 ; Vol. 14, No. 11. pp. 1273-1281.
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