Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia

Genes or environment?

Lai Fong Chan, Clement Zai, Marcellino Monda, Steven Potkin, James L. Kennedy, Gary Remington, Jeffrey Lieberman, Herbert Y. Meltzer, Vincenzo De Luca

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aim: This study explored the role of self-reported ethnicity and genetic ancestry on antipsychotic (AP)-induced weight gain and tardive dyskinesia (TD) in schizophrenia. Patients and methods: Ethnicity was determined by self-report as well as Structure analysis of 190 SNPs selected from HapMap3, genotyped using a customized Illumina BeadChip. Age, gender, baseline weight and AP response using Brief Psychiatric Rating Scale were assessed. Multivariate regression models for AP-induced weight gain and TD, based on the Abnormal Involuntary Movement Scale were constructed. Results: African-American ethnicity (self-report, p = 0.021 and Structure analysis, p = 0.042) predicted AP-induced weight gain but not TD (self-report, p = 0.408 and Structure analysis, p = 0.714). Conclusion: Self-reported African-American ethnicity seemed to better predict AP-induced weight gain in schizophrenia compared with genetic ancestry, suggesting a possible role of environmental in addition to genetic factors. Future larger studies are needed to clarify specific gene-environment mechanisms mediating the effect of ethnicity on AP-induced weight gain.

Original languageEnglish
Pages (from-to)1273-1281
Number of pages9
JournalPharmacogenomics
Volume14
Issue number11
DOIs
Publication statusPublished - 2013

Fingerprint

Antipsychotic Agents
Weight Gain
Self Report
Genes
African Americans
Schizophrenia
Brief Psychiatric Rating Scale
Single Nucleotide Polymorphism
Tardive Dyskinesia
Weights and Measures

Keywords

  • antipsychotic-induced weight gain
  • environment
  • genetics
  • schizophrenia
  • self-reported ethnicity
  • tardive dyskinesia

ASJC Scopus subject areas

  • Pharmacology
  • Genetics
  • Molecular Medicine
  • Medicine(all)

Cite this

Chan, L. F., Zai, C., Monda, M., Potkin, S., Kennedy, J. L., Remington, G., ... De Luca, V. (2013). Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia: Genes or environment? Pharmacogenomics, 14(11), 1273-1281. https://doi.org/10.2217/pgs.13.127

Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia : Genes or environment? / Chan, Lai Fong; Zai, Clement; Monda, Marcellino; Potkin, Steven; Kennedy, James L.; Remington, Gary; Lieberman, Jeffrey; Meltzer, Herbert Y.; De Luca, Vincenzo.

In: Pharmacogenomics, Vol. 14, No. 11, 2013, p. 1273-1281.

Research output: Contribution to journalArticle

Chan, LF, Zai, C, Monda, M, Potkin, S, Kennedy, JL, Remington, G, Lieberman, J, Meltzer, HY & De Luca, V 2013, 'Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia: Genes or environment?', Pharmacogenomics, vol. 14, no. 11, pp. 1273-1281. https://doi.org/10.2217/pgs.13.127
Chan, Lai Fong ; Zai, Clement ; Monda, Marcellino ; Potkin, Steven ; Kennedy, James L. ; Remington, Gary ; Lieberman, Jeffrey ; Meltzer, Herbert Y. ; De Luca, Vincenzo. / Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia : Genes or environment?. In: Pharmacogenomics. 2013 ; Vol. 14, No. 11. pp. 1273-1281.
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