Role of 3-aminopropyltriethoxysilane in the preparation of mesoporous silica nanoparticles for ibuprofen delivery

Effect on physicochemical properties

Kamarudin Nur Hidayatul Nazirah, A. A. Jalil, S. Triwahyono, N. F M Salleh, A. H. Karim, R. R. Mukti, B. H. Hameed, A. Ahmad

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The development of mesoporous silica nanoparticle-based platforms for a controlled drug delivery was studied. Mesoporous silica nanoparticles (MSN) was synthesized and modified with 3-aminopropyltriethoxysilane (APTES) using co-condensation (MSNco) and post-grafting (MSNpost) methods. X-ray diffraction (XRD) and transmission electron microscopy (TEM) data confirmed the formation of ordered mesostructured silica nanoparticles. The performance of MSNs was then tested on an ibuprofen immobilization and release. The results revealed that unmodified MSN demonstrated the best immobilization rate and capacity of ibuprofen (98%), MSNpost exhibited higher ibuprofen adsorption (78%) as compared to MSNco (71%), suggesting the modification method is not the dominant factor for the adsorption studied. In fact, according to the FT-IR results, the silanol groups density was found to be the contributing factor that affected the adsorption. The in vitro drug release was also investigated with simulated biological fluids. In 20 h, MSN co showed the fastest release of ibuprofen (100%), followed by MSN (50%) and MSNpost (38%). Both pore size and amine groups influenced the rate of the release process. From the results, MSN and MSNpost is suggested to have suitable features for slow drug release which provides constant release over a defined period to avoid repeated administration. While MSNco could be best employed as a fast release system that provides initial burst of drug release to achieve rapid and maximum relief.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalMicroporous and Mesoporous Materials
Volume180
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Ibuprofen
Silicon Dioxide
delivery
Silica
Nanoparticles
silicon dioxide
nanoparticles
preparation
drugs
immobilization
Adsorption
adsorption
Pharmaceutical Preparations
Controlled drug delivery
gamma-aminopropyltriethoxysilane
Pore size
Amines
Condensation
bursts
amines

Keywords

  • Amine
  • Drug delivery
  • Ibuprofen
  • Mesoporous silica nanoparticles
  • Modification

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Role of 3-aminopropyltriethoxysilane in the preparation of mesoporous silica nanoparticles for ibuprofen delivery : Effect on physicochemical properties. / Nur Hidayatul Nazirah, Kamarudin; Jalil, A. A.; Triwahyono, S.; Salleh, N. F M; Karim, A. H.; Mukti, R. R.; Hameed, B. H.; Ahmad, A.

In: Microporous and Mesoporous Materials, Vol. 180, 2013, p. 235-241.

Research output: Contribution to journalArticle

Nur Hidayatul Nazirah, Kamarudin ; Jalil, A. A. ; Triwahyono, S. ; Salleh, N. F M ; Karim, A. H. ; Mukti, R. R. ; Hameed, B. H. ; Ahmad, A. / Role of 3-aminopropyltriethoxysilane in the preparation of mesoporous silica nanoparticles for ibuprofen delivery : Effect on physicochemical properties. In: Microporous and Mesoporous Materials. 2013 ; Vol. 180. pp. 235-241.
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AU - Triwahyono, S.

AU - Salleh, N. F M

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