Risk factors of erectile dysfunction in patients receiving methadone maintenance therapy

Nik Ruzyanei Nik Jaafar, Noormazita Mislan, Salina Abdul Aziz, Azlin Baharudin, Normala Ibrahim, Marhani Midin, Srijit Das, Hatta Sidi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Introduction: While methadone effectively treats opiate dependence, the side effect of erectile dysfunction (ED) may interfere with treatment adherence and benefits. Aim: To determine the rate of ED and the associated factors which predict ED in male patients on methadone maintenance therapy (MMT) in a Malaysian population. Main Outcome Measures: The main outcome measures were the International Index of Erectile Function-15 (IIEF-15) and the Beck Depression Inventory (BDI). Methods: A total of 108 participants diagnosed with heroin dependence were assessed. We used the Structured Clinical Interview for DSM-IV Axis-I Disorders (SCID-I) on subjects who received MMT, and they were assessed using the IIEF-15, the BDI, and measures of other clinical and sociodemographic variables. Results: The rate of ED among men on MMT was 68.5% (mild ED, 36.1%; mild to moderate ED, 22.2%; severe ED, 3.7%). The mean age of the participants was 43.45 years. Older age (P=0.002), concurrent illicit heroin use (P=0.024), and having an older partner (P=0.039) were significantly associated with ED. Following multivariate analysis, it was found that older age was the only significant predictor of ED, with an adjusted odds ratio of 1.07 (95% CI=1.02-1.16). Methadone dose and duration of methadone treatment were not significantly associated with ED. Conclusion: ED was highly prevalent among male patients on MMT. This suggests that there is a need for routine assessment of sexual function in patients on methadone. Among the risk factors, age was the only factor that was significantly associated with ED. The current use of MMT in Malaysia in terms of dosage and duration did not pose a significant risk for ED.

Original languageEnglish
Pages (from-to)2069-2076
Number of pages8
JournalJournal of Sexual Medicine
Volume10
Issue number8
DOIs
Publication statusPublished - 2013

Fingerprint

Methadone
Erectile Dysfunction
Therapeutics
Outcome Assessment (Health Care)
Depression
Heroin Dependence
Opioid-Related Disorders
Equipment and Supplies
Needs Assessment
Malaysia
Heroin
Diagnostic and Statistical Manual of Mental Disorders
Multivariate Analysis
Odds Ratio

Keywords

  • Erectile Dysfunction
  • Methadone Therapy
  • Opiate Dependence

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Medicine(all)

Cite this

Risk factors of erectile dysfunction in patients receiving methadone maintenance therapy. / Nik Jaafar, Nik Ruzyanei; Mislan, Noormazita; Abdul Aziz, Salina; Baharudin, Azlin; Ibrahim, Normala; Midin, Marhani; Das, Srijit; Sidi, Hatta.

In: Journal of Sexual Medicine, Vol. 10, No. 8, 2013, p. 2069-2076.

Research output: Contribution to journalArticle

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abstract = "Introduction: While methadone effectively treats opiate dependence, the side effect of erectile dysfunction (ED) may interfere with treatment adherence and benefits. Aim: To determine the rate of ED and the associated factors which predict ED in male patients on methadone maintenance therapy (MMT) in a Malaysian population. Main Outcome Measures: The main outcome measures were the International Index of Erectile Function-15 (IIEF-15) and the Beck Depression Inventory (BDI). Methods: A total of 108 participants diagnosed with heroin dependence were assessed. We used the Structured Clinical Interview for DSM-IV Axis-I Disorders (SCID-I) on subjects who received MMT, and they were assessed using the IIEF-15, the BDI, and measures of other clinical and sociodemographic variables. Results: The rate of ED among men on MMT was 68.5{\%} (mild ED, 36.1{\%}; mild to moderate ED, 22.2{\%}; severe ED, 3.7{\%}). The mean age of the participants was 43.45 years. Older age (P=0.002), concurrent illicit heroin use (P=0.024), and having an older partner (P=0.039) were significantly associated with ED. Following multivariate analysis, it was found that older age was the only significant predictor of ED, with an adjusted odds ratio of 1.07 (95{\%} CI=1.02-1.16). Methadone dose and duration of methadone treatment were not significantly associated with ED. Conclusion: ED was highly prevalent among male patients on MMT. This suggests that there is a need for routine assessment of sexual function in patients on methadone. Among the risk factors, age was the only factor that was significantly associated with ED. The current use of MMT in Malaysia in terms of dosage and duration did not pose a significant risk for ED.",
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AU - Nik Jaafar, Nik Ruzyanei

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AU - Abdul Aziz, Salina

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AU - Ibrahim, Normala

AU - Midin, Marhani

AU - Das, Srijit

AU - Sidi, Hatta

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AB - Introduction: While methadone effectively treats opiate dependence, the side effect of erectile dysfunction (ED) may interfere with treatment adherence and benefits. Aim: To determine the rate of ED and the associated factors which predict ED in male patients on methadone maintenance therapy (MMT) in a Malaysian population. Main Outcome Measures: The main outcome measures were the International Index of Erectile Function-15 (IIEF-15) and the Beck Depression Inventory (BDI). Methods: A total of 108 participants diagnosed with heroin dependence were assessed. We used the Structured Clinical Interview for DSM-IV Axis-I Disorders (SCID-I) on subjects who received MMT, and they were assessed using the IIEF-15, the BDI, and measures of other clinical and sociodemographic variables. Results: The rate of ED among men on MMT was 68.5% (mild ED, 36.1%; mild to moderate ED, 22.2%; severe ED, 3.7%). The mean age of the participants was 43.45 years. Older age (P=0.002), concurrent illicit heroin use (P=0.024), and having an older partner (P=0.039) were significantly associated with ED. Following multivariate analysis, it was found that older age was the only significant predictor of ED, with an adjusted odds ratio of 1.07 (95% CI=1.02-1.16). Methadone dose and duration of methadone treatment were not significantly associated with ED. Conclusion: ED was highly prevalent among male patients on MMT. This suggests that there is a need for routine assessment of sexual function in patients on methadone. Among the risk factors, age was the only factor that was significantly associated with ED. The current use of MMT in Malaysia in terms of dosage and duration did not pose a significant risk for ED.

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