Risk factors for infection in Malaysian patients with systemic lupus erythematosus

N. I J Paton, I. K S Cheong, N. C T Kong, M. Segasothy

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Abstract

    To determine the incidence, types and risk factors for infection in systemic lupus erythematosus (SLE) patients in Kuala Lumpur, Malaysia, we retrospectively reviewed the medical records of 102 patients with definite SLE attending a specialist clinic. Details of major infections (pneumonia or severe infection requiring intravenous therapy) and minor infections, and their time of onset in relation to immunosuppressive therapy and disease flares were recorded. There were 77 major and 163 minor infections during 564 patient-years of follow-up. In the month following a course of pulse methylprednisolone, the incidence of major infection was 20 times higher and the incidence of minor infection was 10 times higher than at other periods (p < 0.0001). In the month after disease flare, the incidence of major infection was 10 times higher and the incidence of minor infection six times higher than at other times (p < 0.0001). After allowing for methylprednisolone therapy and disease flares, there was no increase in the rate of infections during treatment with azathioprine, oral or intravenous cyclophosphamide. There was no effect of renal involvement on infection rate.

    Original languageEnglish
    Pages (from-to)531-538
    Number of pages8
    JournalQJM - Monthly Journal of the Association of Physicians
    Volume89
    Issue number7
    Publication statusPublished - Jul 1996

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    Systemic Lupus Erythematosus
    Infection
    Incidence
    Methylprednisolone
    Malaysia
    Azathioprine
    Therapeutics
    Immunosuppressive Agents
    Cyclophosphamide
    Medical Records
    Pneumonia
    Kidney

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Paton, N. I. J., Cheong, I. K. S., Kong, N. C. T., & Segasothy, M. (1996). Risk factors for infection in Malaysian patients with systemic lupus erythematosus. QJM - Monthly Journal of the Association of Physicians, 89(7), 531-538.

    Risk factors for infection in Malaysian patients with systemic lupus erythematosus. / Paton, N. I J; Cheong, I. K S; Kong, N. C T; Segasothy, M.

    In: QJM - Monthly Journal of the Association of Physicians, Vol. 89, No. 7, 07.1996, p. 531-538.

    Research output: Contribution to journalArticle

    Paton, N. I J ; Cheong, I. K S ; Kong, N. C T ; Segasothy, M. / Risk factors for infection in Malaysian patients with systemic lupus erythematosus. In: QJM - Monthly Journal of the Association of Physicians. 1996 ; Vol. 89, No. 7. pp. 531-538.
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