Revisiting the association between candidal infection and carcinoma, particularly oral squamous cell carcinoma

Marina Mohd Bakri, Haizal Mohd Hussaini, Ann Holmes, Richard David Cannon, Alison Mary Rich

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: Tobacco and alcohol are risk factors associated with cancer of the upper aerodigestive tract, but increasingly the role of infection and chronic inflammation is recognized as being significant in cancer development. Bacteria, particularly Helicobacter pylori, and viruses such as members of the human papilloma virus family and hepatitis B and C are strongly implicated as etiological factors in certain cancers. There is less evidence for an association between fungi and cancer, although it has been recognized for many years that white patches on the oral mucosa, which are infected with Candida, have a greater likelihood of undergoing malignant transformation than those that are not infected. Objective: This article reviews the association between the development of oral squamous cell carcinoma in potentially malignant oral lesions with chronic candidal infection and describes mechanisms that may be involved in Candida-associated malignant transformation.

Original languageEnglish
Article number5780
JournalJournal of Oral Microbiology
Volume2
Issue number2010
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Squamous Cell Carcinoma
Carcinoma
Infection
Candida
Papillomaviridae
Neoplasms
Mouth Mucosa
Hepatitis C
Hepatitis B
Helicobacter pylori
Tobacco
Fungi
Alcohols
Viruses
Inflammation
Bacteria

Keywords

  • Acetaldehyde
  • Candida albicans
  • Inflammation and cancer
  • Oral cancer
  • Proinflammatory cytokines

ASJC Scopus subject areas

  • Dentistry (miscellaneous)
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Revisiting the association between candidal infection and carcinoma, particularly oral squamous cell carcinoma. / Bakri, Marina Mohd; Hussaini, Haizal Mohd; Holmes, Ann; Cannon, Richard David; Rich, Alison Mary.

In: Journal of Oral Microbiology, Vol. 2, No. 2010, 5780, 2010.

Research output: Contribution to journalArticle

Bakri, Marina Mohd ; Hussaini, Haizal Mohd ; Holmes, Ann ; Cannon, Richard David ; Rich, Alison Mary. / Revisiting the association between candidal infection and carcinoma, particularly oral squamous cell carcinoma. In: Journal of Oral Microbiology. 2010 ; Vol. 2, No. 2010.
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