Reviewing the molecular mechanisms which increase endometrial cancer (EC) risk in women with polycystic ovarian syndrome (PCOS)

Time for paradigm shift?

Mohamad Nasir Shafiee, Caroline Chapman, David Barrett, Jafaru Abu, William Atiomo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Endometrial cancer (EC) is the commonest gynaecological cancer in North American and European women. Even though it has been shown that women with polycystic ovary syndrome (PCOS) have a three-fold increase in the risk of developing EC compared to women without PCOS, the precise molecular mechanisms which increase EC risk in women with PCOS remain unclear. Clinical strategies to prevent EC in PCOS are therefore not well researched and understood. Although raised estrogen levels, hyperinsulinaemia and, reduced apoptosis have been suggested as potential mechanisms, there is a lack of clarity about how these factors and other factors may interact to increase EC risk in PCOS. This article reviews the literature, on the potential molecular links between PCOS and EC but argues for a paradigm shift, to a systems biology-based approach in future research into the molecular links between PCOS and EC. The potential challenges of a systems biology-based approach are outlined but not considered insurmountable.

Original languageEnglish
Pages (from-to)489-492
Number of pages4
JournalGynecologic Oncology
Volume131
Issue number2
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Polycystic Ovary Syndrome
Endometrial Neoplasms
Systems Biology
Ovarian Neoplasms
Hyperinsulinism
Estrogens
Apoptosis
Neoplasms

Keywords

  • Endometrial cancer
  • Genomic
  • IGF
  • Metabolomics
  • PCOS

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Reviewing the molecular mechanisms which increase endometrial cancer (EC) risk in women with polycystic ovarian syndrome (PCOS) : Time for paradigm shift? / Shafiee, Mohamad Nasir; Chapman, Caroline; Barrett, David; Abu, Jafaru; Atiomo, William.

In: Gynecologic Oncology, Vol. 131, No. 2, 11.2013, p. 489-492.

Research output: Contribution to journalArticle

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