Abstract
Endometrial cancer (EC) is the commonest gynaecological cancer in North American and European women. Even though it has been shown that women with polycystic ovary syndrome (PCOS) have a three-fold increase in the risk of developing EC compared to women without PCOS, the precise molecular mechanisms which increase EC risk in women with PCOS remain unclear. Clinical strategies to prevent EC in PCOS are therefore not well researched and understood. Although raised estrogen levels, hyperinsulinaemia and, reduced apoptosis have been suggested as potential mechanisms, there is a lack of clarity about how these factors and other factors may interact to increase EC risk in PCOS. This article reviews the literature, on the potential molecular links between PCOS and EC but argues for a paradigm shift, to a systems biology-based approach in future research into the molecular links between PCOS and EC. The potential challenges of a systems biology-based approach are outlined but not considered insurmountable.
| Original language | English |
|---|---|
| Pages (from-to) | 489-492 |
| Number of pages | 4 |
| Journal | Gynecologic Oncology |
| Volume | 131 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Nov 2013 |
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Keywords
- Endometrial cancer
- Genomic
- IGF
- Metabolomics
- PCOS
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Oncology
Cite this
Reviewing the molecular mechanisms which increase endometrial cancer (EC) risk in women with polycystic ovarian syndrome (PCOS) : Time for paradigm shift? / Shafiee, Mohamad Nasir; Chapman, Caroline; Barrett, David; Abu, Jafaru; Atiomo, William.
In: Gynecologic Oncology, Vol. 131, No. 2, 11.2013, p. 489-492.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reviewing the molecular mechanisms which increase endometrial cancer (EC) risk in women with polycystic ovarian syndrome (PCOS)
T2 - Time for paradigm shift?
AU - Shafiee, Mohamad Nasir
AU - Chapman, Caroline
AU - Barrett, David
AU - Abu, Jafaru
AU - Atiomo, William
PY - 2013/11
Y1 - 2013/11
N2 - Endometrial cancer (EC) is the commonest gynaecological cancer in North American and European women. Even though it has been shown that women with polycystic ovary syndrome (PCOS) have a three-fold increase in the risk of developing EC compared to women without PCOS, the precise molecular mechanisms which increase EC risk in women with PCOS remain unclear. Clinical strategies to prevent EC in PCOS are therefore not well researched and understood. Although raised estrogen levels, hyperinsulinaemia and, reduced apoptosis have been suggested as potential mechanisms, there is a lack of clarity about how these factors and other factors may interact to increase EC risk in PCOS. This article reviews the literature, on the potential molecular links between PCOS and EC but argues for a paradigm shift, to a systems biology-based approach in future research into the molecular links between PCOS and EC. The potential challenges of a systems biology-based approach are outlined but not considered insurmountable.
AB - Endometrial cancer (EC) is the commonest gynaecological cancer in North American and European women. Even though it has been shown that women with polycystic ovary syndrome (PCOS) have a three-fold increase in the risk of developing EC compared to women without PCOS, the precise molecular mechanisms which increase EC risk in women with PCOS remain unclear. Clinical strategies to prevent EC in PCOS are therefore not well researched and understood. Although raised estrogen levels, hyperinsulinaemia and, reduced apoptosis have been suggested as potential mechanisms, there is a lack of clarity about how these factors and other factors may interact to increase EC risk in PCOS. This article reviews the literature, on the potential molecular links between PCOS and EC but argues for a paradigm shift, to a systems biology-based approach in future research into the molecular links between PCOS and EC. The potential challenges of a systems biology-based approach are outlined but not considered insurmountable.
KW - Endometrial cancer
KW - Genomic
KW - IGF
KW - Metabolomics
KW - PCOS
UR - http://www.scopus.com/inward/record.url?scp=84886085794&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886085794&partnerID=8YFLogxK
U2 - 10.1016/j.ygyno.2013.06.032
DO - 10.1016/j.ygyno.2013.06.032
M3 - Article
C2 - 23822891
AN - SCOPUS:84886085794
VL - 131
SP - 489
EP - 492
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 2
ER -