Revalidation of the score for neonatal acute physiology in the Vermont Oxford Network

John A F Zupancic, Douglas K. Richardson, Jeffrey D. Horbar, Joseph H. Carpenter, Shoo K. Lee, Gabriel J. Escobar, Esmond Arrindell, David Corcoran, Douglas Dransfield, Keith Gallaher, Jeffrey Gerdes, Roger Hinson, David Hoffman, Patrick Lewallen, Allen Merritt, Jeanne Webb, Vijay Baichoo, Gregory Samson, Su Boynton, Pauline GrazianoJoaquim Pinheiro, Agnes Salvador, David Schutzman, Brenda Douglass, Kim Reese, Dianna Garner, Dan Sobel, Pam McKinley, Jonathan Whitfield, John Zupancic, Keith J. Gallaher, Anne Sheaves, Cyndi Atkinson, Philippe S. Friedlich, Tina Bair, Judy Ohlinger, Howard S. Cohen, Constance McConnell, Michael Friedman, Lloyd Tinianow, Kathy Leef, David Paul, Jack Lorenz, Kiyoko Ohira-Kist, Patty Lore, Rick McClead, Cynthia Dembofsky, Sonia Hulman, Ed Beaumont, Dinah Sutton, William MacKendrick, Sue Wolf, David Shutzman, Craig Anderson, Nancy Wagner, Raul F. Cifuentes, MaryAnn Tyler, Savitri Kumar, Bonnie Malmberg, Sture Andersson, Marita Suni, Judy Burke, Jeffrey Merrill, Bharti Razdan, Misrak Tadesse, Robin Baker, Rebecca Beck, Lauren Johnson-Robbins, Jagjit Teji, Rohitkumar Vasa, Arthur Strauss, Douglas Carbine, Robert McArtor, Jane Ranney, Daniele Merazzi, Ihor Bilyk, Soraya Abbasi, Wendy Boehm, Patricia Ittmann, Anthony Barone, Anantham Harin, Carolyn Herrington, Padmani Karna, Barbara Long, Arturo Santos, Maryanne Merritt, T. Allen Merritt, Maria Duenas, Brenda Bigley, Dennis Crouse, Jeffrey Garland, Susan Kannenberg, Michael Dunn, Allyson Nichols, Patrick LeBlanc, Meena LaCorte, Gerald D. Brown, David J. Hoffman, Francis J. Bednarek, Mary L. Naples, Nem Yun Boo, Juriza Ismail, Al Cain, Ronald Dechert, Barry Bloom, Paula Delmore, Roger M. Hinson

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

OBJECTIVES. Our specific objectives were (1) to document the performance of the revised Score for Neonatal Acute Physiology and the revised Score for Neonatal Acute Physiology Perinatal Extension in predicting death in the Vermont Oxford Network, compared with published normative values; (2) to determine whether this performance could be improved through recalibration of the weights for individual score items; (3) to determine the impact of including congenital anomalies in the predictive model; and (4) to compare performance against that of the Vermont Oxford Network risk adjustment, separately and in combination. METHODS. Fifty-eight Vermont Oxford Network centers collected data prospectively for the revised Score for Neonatal Acute Physiology in the first 12 hours after admission of infants in 2002. RESULTS. Data were collected for 10 469 infants, and analyses were undertaken for 9897 who met inclusion criteria. The median revised Score for Neonatal Acute Physiology was 5, and the mean birth weight was 1951 g. Recalibration of the revised Score for Neonatal Acute Physiology and revised Score for Neonatal Acute Physiology Perinatal Extension resulted in minimal changes in their discriminatory abilities. The Vermont Oxford Network risk adjustment performed similarly, compared with the revised Score for Neonatal Acute Physiology Perinatal Extension. CONCLUSIONS. Current score performance was similar to that observed previously, which suggests that the revised Score for Neonatal Acute Physiology and revised Score for Neonatal Acute Physiology Perinatal Extension have not decalibrated over the 7 years since the first cohort was assembled, despite advances in neonatal care during that period. Addition of congenital anomalies to the revised Score for Neonatal Acute Physiology Perinatal Extension improved discrimination significantly, particularly for infants with birth weights of >1500 g. The Vermont Oxford Network risk adjustment performed similarly, compared with the revised Score for Neonatal Acute Physiology Perinatal Extension.

Original languageEnglish
JournalPediatrics
Volume119
Issue number1
DOIs
Publication statusPublished - Jan 2007

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Risk Adjustment
Birth Weight
Weights and Measures

Keywords

  • Illness severity
  • Infant
  • Newborn
  • Predictive value of tests

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Zupancic, J. A. F., Richardson, D. K., Horbar, J. D., Carpenter, J. H., Lee, S. K., Escobar, G. J., ... Hinson, R. M. (2007). Revalidation of the score for neonatal acute physiology in the Vermont Oxford Network. Pediatrics, 119(1). https://doi.org/10.1542/peds.2005-2957

Revalidation of the score for neonatal acute physiology in the Vermont Oxford Network. / Zupancic, John A F; Richardson, Douglas K.; Horbar, Jeffrey D.; Carpenter, Joseph H.; Lee, Shoo K.; Escobar, Gabriel J.; Arrindell, Esmond; Corcoran, David; Dransfield, Douglas; Gallaher, Keith; Gerdes, Jeffrey; Hinson, Roger; Hoffman, David; Lewallen, Patrick; Merritt, Allen; Webb, Jeanne; Baichoo, Vijay; Samson, Gregory; Boynton, Su; Graziano, Pauline; Pinheiro, Joaquim; Salvador, Agnes; Schutzman, David; Douglass, Brenda; Reese, Kim; Garner, Dianna; Sobel, Dan; McKinley, Pam; Whitfield, Jonathan; Zupancic, John; Gallaher, Keith J.; Sheaves, Anne; Atkinson, Cyndi; Friedlich, Philippe S.; Bair, Tina; Ohlinger, Judy; Cohen, Howard S.; McConnell, Constance; Friedman, Michael; Tinianow, Lloyd; Leef, Kathy; Paul, David; Lorenz, Jack; Ohira-Kist, Kiyoko; Lore, Patty; McClead, Rick; Dembofsky, Cynthia; Hulman, Sonia; Beaumont, Ed; Sutton, Dinah; MacKendrick, William; Wolf, Sue; Shutzman, David; Anderson, Craig; Wagner, Nancy; Cifuentes, Raul F.; Tyler, MaryAnn; Kumar, Savitri; Malmberg, Bonnie; Andersson, Sture; Suni, Marita; Burke, Judy; Merrill, Jeffrey; Razdan, Bharti; Tadesse, Misrak; Baker, Robin; Beck, Rebecca; Johnson-Robbins, Lauren; Teji, Jagjit; Vasa, Rohitkumar; Strauss, Arthur; Carbine, Douglas; McArtor, Robert; Ranney, Jane; Merazzi, Daniele; Bilyk, Ihor; Abbasi, Soraya; Boehm, Wendy; Ittmann, Patricia; Barone, Anthony; Harin, Anantham; Herrington, Carolyn; Karna, Padmani; Long, Barbara; Santos, Arturo; Merritt, Maryanne; Merritt, T. Allen; Duenas, Maria; Bigley, Brenda; Crouse, Dennis; Garland, Jeffrey; Kannenberg, Susan; Dunn, Michael; Nichols, Allyson; LeBlanc, Patrick; LaCorte, Meena; Brown, Gerald D.; Hoffman, David J.; Bednarek, Francis J.; Naples, Mary L.; Boo, Nem Yun; Ismail, Juriza; Cain, Al; Dechert, Ronald; Bloom, Barry; Delmore, Paula; Hinson, Roger M.

In: Pediatrics, Vol. 119, No. 1, 01.2007.

Research output: Contribution to journalArticle

Zupancic, JAF, Richardson, DK, Horbar, JD, Carpenter, JH, Lee, SK, Escobar, GJ, Arrindell, E, Corcoran, D, Dransfield, D, Gallaher, K, Gerdes, J, Hinson, R, Hoffman, D, Lewallen, P, Merritt, A, Webb, J, Baichoo, V, Samson, G, Boynton, S, Graziano, P, Pinheiro, J, Salvador, A, Schutzman, D, Douglass, B, Reese, K, Garner, D, Sobel, D, McKinley, P, Whitfield, J, Zupancic, J, Gallaher, KJ, Sheaves, A, Atkinson, C, Friedlich, PS, Bair, T, Ohlinger, J, Cohen, HS, McConnell, C, Friedman, M, Tinianow, L, Leef, K, Paul, D, Lorenz, J, Ohira-Kist, K, Lore, P, McClead, R, Dembofsky, C, Hulman, S, Beaumont, E, Sutton, D, MacKendrick, W, Wolf, S, Shutzman, D, Anderson, C, Wagner, N, Cifuentes, RF, Tyler, M, Kumar, S, Malmberg, B, Andersson, S, Suni, M, Burke, J, Merrill, J, Razdan, B, Tadesse, M, Baker, R, Beck, R, Johnson-Robbins, L, Teji, J, Vasa, R, Strauss, A, Carbine, D, McArtor, R, Ranney, J, Merazzi, D, Bilyk, I, Abbasi, S, Boehm, W, Ittmann, P, Barone, A, Harin, A, Herrington, C, Karna, P, Long, B, Santos, A, Merritt, M, Merritt, TA, Duenas, M, Bigley, B, Crouse, D, Garland, J, Kannenberg, S, Dunn, M, Nichols, A, LeBlanc, P, LaCorte, M, Brown, GD, Hoffman, DJ, Bednarek, FJ, Naples, ML, Boo, NY, Ismail, J, Cain, A, Dechert, R, Bloom, B, Delmore, P & Hinson, RM 2007, 'Revalidation of the score for neonatal acute physiology in the Vermont Oxford Network', Pediatrics, vol. 119, no. 1. https://doi.org/10.1542/peds.2005-2957
Zupancic JAF, Richardson DK, Horbar JD, Carpenter JH, Lee SK, Escobar GJ et al. Revalidation of the score for neonatal acute physiology in the Vermont Oxford Network. Pediatrics. 2007 Jan;119(1). https://doi.org/10.1542/peds.2005-2957
Zupancic, John A F ; Richardson, Douglas K. ; Horbar, Jeffrey D. ; Carpenter, Joseph H. ; Lee, Shoo K. ; Escobar, Gabriel J. ; Arrindell, Esmond ; Corcoran, David ; Dransfield, Douglas ; Gallaher, Keith ; Gerdes, Jeffrey ; Hinson, Roger ; Hoffman, David ; Lewallen, Patrick ; Merritt, Allen ; Webb, Jeanne ; Baichoo, Vijay ; Samson, Gregory ; Boynton, Su ; Graziano, Pauline ; Pinheiro, Joaquim ; Salvador, Agnes ; Schutzman, David ; Douglass, Brenda ; Reese, Kim ; Garner, Dianna ; Sobel, Dan ; McKinley, Pam ; Whitfield, Jonathan ; Zupancic, John ; Gallaher, Keith J. ; Sheaves, Anne ; Atkinson, Cyndi ; Friedlich, Philippe S. ; Bair, Tina ; Ohlinger, Judy ; Cohen, Howard S. ; McConnell, Constance ; Friedman, Michael ; Tinianow, Lloyd ; Leef, Kathy ; Paul, David ; Lorenz, Jack ; Ohira-Kist, Kiyoko ; Lore, Patty ; McClead, Rick ; Dembofsky, Cynthia ; Hulman, Sonia ; Beaumont, Ed ; Sutton, Dinah ; MacKendrick, William ; Wolf, Sue ; Shutzman, David ; Anderson, Craig ; Wagner, Nancy ; Cifuentes, Raul F. ; Tyler, MaryAnn ; Kumar, Savitri ; Malmberg, Bonnie ; Andersson, Sture ; Suni, Marita ; Burke, Judy ; Merrill, Jeffrey ; Razdan, Bharti ; Tadesse, Misrak ; Baker, Robin ; Beck, Rebecca ; Johnson-Robbins, Lauren ; Teji, Jagjit ; Vasa, Rohitkumar ; Strauss, Arthur ; Carbine, Douglas ; McArtor, Robert ; Ranney, Jane ; Merazzi, Daniele ; Bilyk, Ihor ; Abbasi, Soraya ; Boehm, Wendy ; Ittmann, Patricia ; Barone, Anthony ; Harin, Anantham ; Herrington, Carolyn ; Karna, Padmani ; Long, Barbara ; Santos, Arturo ; Merritt, Maryanne ; Merritt, T. Allen ; Duenas, Maria ; Bigley, Brenda ; Crouse, Dennis ; Garland, Jeffrey ; Kannenberg, Susan ; Dunn, Michael ; Nichols, Allyson ; LeBlanc, Patrick ; LaCorte, Meena ; Brown, Gerald D. ; Hoffman, David J. ; Bednarek, Francis J. ; Naples, Mary L. ; Boo, Nem Yun ; Ismail, Juriza ; Cain, Al ; Dechert, Ronald ; Bloom, Barry ; Delmore, Paula ; Hinson, Roger M. / Revalidation of the score for neonatal acute physiology in the Vermont Oxford Network. In: Pediatrics. 2007 ; Vol. 119, No. 1.
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title = "Revalidation of the score for neonatal acute physiology in the Vermont Oxford Network",
abstract = "OBJECTIVES. Our specific objectives were (1) to document the performance of the revised Score for Neonatal Acute Physiology and the revised Score for Neonatal Acute Physiology Perinatal Extension in predicting death in the Vermont Oxford Network, compared with published normative values; (2) to determine whether this performance could be improved through recalibration of the weights for individual score items; (3) to determine the impact of including congenital anomalies in the predictive model; and (4) to compare performance against that of the Vermont Oxford Network risk adjustment, separately and in combination. METHODS. Fifty-eight Vermont Oxford Network centers collected data prospectively for the revised Score for Neonatal Acute Physiology in the first 12 hours after admission of infants in 2002. RESULTS. Data were collected for 10 469 infants, and analyses were undertaken for 9897 who met inclusion criteria. The median revised Score for Neonatal Acute Physiology was 5, and the mean birth weight was 1951 g. Recalibration of the revised Score for Neonatal Acute Physiology and revised Score for Neonatal Acute Physiology Perinatal Extension resulted in minimal changes in their discriminatory abilities. The Vermont Oxford Network risk adjustment performed similarly, compared with the revised Score for Neonatal Acute Physiology Perinatal Extension. CONCLUSIONS. Current score performance was similar to that observed previously, which suggests that the revised Score for Neonatal Acute Physiology and revised Score for Neonatal Acute Physiology Perinatal Extension have not decalibrated over the 7 years since the first cohort was assembled, despite advances in neonatal care during that period. Addition of congenital anomalies to the revised Score for Neonatal Acute Physiology Perinatal Extension improved discrimination significantly, particularly for infants with birth weights of >1500 g. The Vermont Oxford Network risk adjustment performed similarly, compared with the revised Score for Neonatal Acute Physiology Perinatal Extension.",
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TY - JOUR

T1 - Revalidation of the score for neonatal acute physiology in the Vermont Oxford Network

AU - Zupancic, John A F

AU - Richardson, Douglas K.

AU - Horbar, Jeffrey D.

AU - Carpenter, Joseph H.

AU - Lee, Shoo K.

AU - Escobar, Gabriel J.

AU - Arrindell, Esmond

AU - Corcoran, David

AU - Dransfield, Douglas

AU - Gallaher, Keith

AU - Gerdes, Jeffrey

AU - Hinson, Roger

AU - Hoffman, David

AU - Lewallen, Patrick

AU - Merritt, Allen

AU - Webb, Jeanne

AU - Baichoo, Vijay

AU - Samson, Gregory

AU - Boynton, Su

AU - Graziano, Pauline

AU - Pinheiro, Joaquim

AU - Salvador, Agnes

AU - Schutzman, David

AU - Douglass, Brenda

AU - Reese, Kim

AU - Garner, Dianna

AU - Sobel, Dan

AU - McKinley, Pam

AU - Whitfield, Jonathan

AU - Zupancic, John

AU - Gallaher, Keith J.

AU - Sheaves, Anne

AU - Atkinson, Cyndi

AU - Friedlich, Philippe S.

AU - Bair, Tina

AU - Ohlinger, Judy

AU - Cohen, Howard S.

AU - McConnell, Constance

AU - Friedman, Michael

AU - Tinianow, Lloyd

AU - Leef, Kathy

AU - Paul, David

AU - Lorenz, Jack

AU - Ohira-Kist, Kiyoko

AU - Lore, Patty

AU - McClead, Rick

AU - Dembofsky, Cynthia

AU - Hulman, Sonia

AU - Beaumont, Ed

AU - Sutton, Dinah

AU - MacKendrick, William

AU - Wolf, Sue

AU - Shutzman, David

AU - Anderson, Craig

AU - Wagner, Nancy

AU - Cifuentes, Raul F.

AU - Tyler, MaryAnn

AU - Kumar, Savitri

AU - Malmberg, Bonnie

AU - Andersson, Sture

AU - Suni, Marita

AU - Burke, Judy

AU - Merrill, Jeffrey

AU - Razdan, Bharti

AU - Tadesse, Misrak

AU - Baker, Robin

AU - Beck, Rebecca

AU - Johnson-Robbins, Lauren

AU - Teji, Jagjit

AU - Vasa, Rohitkumar

AU - Strauss, Arthur

AU - Carbine, Douglas

AU - McArtor, Robert

AU - Ranney, Jane

AU - Merazzi, Daniele

AU - Bilyk, Ihor

AU - Abbasi, Soraya

AU - Boehm, Wendy

AU - Ittmann, Patricia

AU - Barone, Anthony

AU - Harin, Anantham

AU - Herrington, Carolyn

AU - Karna, Padmani

AU - Long, Barbara

AU - Santos, Arturo

AU - Merritt, Maryanne

AU - Merritt, T. Allen

AU - Duenas, Maria

AU - Bigley, Brenda

AU - Crouse, Dennis

AU - Garland, Jeffrey

AU - Kannenberg, Susan

AU - Dunn, Michael

AU - Nichols, Allyson

AU - LeBlanc, Patrick

AU - LaCorte, Meena

AU - Brown, Gerald D.

AU - Hoffman, David J.

AU - Bednarek, Francis J.

AU - Naples, Mary L.

AU - Boo, Nem Yun

AU - Ismail, Juriza

AU - Cain, Al

AU - Dechert, Ronald

AU - Bloom, Barry

AU - Delmore, Paula

AU - Hinson, Roger M.

PY - 2007/1

Y1 - 2007/1

N2 - OBJECTIVES. Our specific objectives were (1) to document the performance of the revised Score for Neonatal Acute Physiology and the revised Score for Neonatal Acute Physiology Perinatal Extension in predicting death in the Vermont Oxford Network, compared with published normative values; (2) to determine whether this performance could be improved through recalibration of the weights for individual score items; (3) to determine the impact of including congenital anomalies in the predictive model; and (4) to compare performance against that of the Vermont Oxford Network risk adjustment, separately and in combination. METHODS. Fifty-eight Vermont Oxford Network centers collected data prospectively for the revised Score for Neonatal Acute Physiology in the first 12 hours after admission of infants in 2002. RESULTS. Data were collected for 10 469 infants, and analyses were undertaken for 9897 who met inclusion criteria. The median revised Score for Neonatal Acute Physiology was 5, and the mean birth weight was 1951 g. Recalibration of the revised Score for Neonatal Acute Physiology and revised Score for Neonatal Acute Physiology Perinatal Extension resulted in minimal changes in their discriminatory abilities. The Vermont Oxford Network risk adjustment performed similarly, compared with the revised Score for Neonatal Acute Physiology Perinatal Extension. CONCLUSIONS. Current score performance was similar to that observed previously, which suggests that the revised Score for Neonatal Acute Physiology and revised Score for Neonatal Acute Physiology Perinatal Extension have not decalibrated over the 7 years since the first cohort was assembled, despite advances in neonatal care during that period. Addition of congenital anomalies to the revised Score for Neonatal Acute Physiology Perinatal Extension improved discrimination significantly, particularly for infants with birth weights of >1500 g. The Vermont Oxford Network risk adjustment performed similarly, compared with the revised Score for Neonatal Acute Physiology Perinatal Extension.

AB - OBJECTIVES. Our specific objectives were (1) to document the performance of the revised Score for Neonatal Acute Physiology and the revised Score for Neonatal Acute Physiology Perinatal Extension in predicting death in the Vermont Oxford Network, compared with published normative values; (2) to determine whether this performance could be improved through recalibration of the weights for individual score items; (3) to determine the impact of including congenital anomalies in the predictive model; and (4) to compare performance against that of the Vermont Oxford Network risk adjustment, separately and in combination. METHODS. Fifty-eight Vermont Oxford Network centers collected data prospectively for the revised Score for Neonatal Acute Physiology in the first 12 hours after admission of infants in 2002. RESULTS. Data were collected for 10 469 infants, and analyses were undertaken for 9897 who met inclusion criteria. The median revised Score for Neonatal Acute Physiology was 5, and the mean birth weight was 1951 g. Recalibration of the revised Score for Neonatal Acute Physiology and revised Score for Neonatal Acute Physiology Perinatal Extension resulted in minimal changes in their discriminatory abilities. The Vermont Oxford Network risk adjustment performed similarly, compared with the revised Score for Neonatal Acute Physiology Perinatal Extension. CONCLUSIONS. Current score performance was similar to that observed previously, which suggests that the revised Score for Neonatal Acute Physiology and revised Score for Neonatal Acute Physiology Perinatal Extension have not decalibrated over the 7 years since the first cohort was assembled, despite advances in neonatal care during that period. Addition of congenital anomalies to the revised Score for Neonatal Acute Physiology Perinatal Extension improved discrimination significantly, particularly for infants with birth weights of >1500 g. The Vermont Oxford Network risk adjustment performed similarly, compared with the revised Score for Neonatal Acute Physiology Perinatal Extension.

KW - Illness severity

KW - Infant

KW - Newborn

KW - Predictive value of tests

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