Retinal nerve fiber layer thickness in chronic obstructive pulmonary disease: An optical coherence tomography study

Yeap Thye Ghee, Mushawiahti Mustapha, Roslan Harun, Syed Zulkifli Syed Zakaria, Jemaima Che Hamzah, Hairul Nizam Harun, Faridah Hanom Annuar

Research output: Contribution to journalArticle

Abstract

Background: To evaluate changes in the retinal nerve fiber layer (RNFL) thickness in patients with chronic obstructive pulmonary disease (COPD) using optical coherence tomography (OCT). Methods: In this case-controlled study, COPD subjects with various disease durations and severity were recruited. The standard global initiative for chronic obstructive lung disease (GOLD) criteria was used to determine the severity of COPD in the subjects. Healthy individuals were recruited as the control group. Peripapillary RNFL thickness was measured using spectral domain OCT. Results: Seventy-one eyes of 71 COPD patients and 71 eyes of healthy controls were examined. The RNFL in all quadrants and the average RNFL were significantly thinner in patients with COPD compared to the control group (p < 0.05). There were significant correlations between severity of COPD and RNFL thickness (p < 0.05) for the average RNFL (r = 0.831) and RNFL in all quadrants (superior RNFL r = 0.736, inferior RNFL r = 0.681, nasal RNFL r = 0.600, and temporal RNFL r = 0.353). Similar significant correlations were found between RNFL thickness and duration of COPD (p < 0.005) for the average RNFL(r = -0.674) and RNFL in all quadrants (superior r = -0.615, inferior r = -0.472, nasal r = -0.484, and temporal r = -0.323). The risk of having a thin RNFL (odds ratio) was 13-fold higher in patients with COPD. Conclusions: These results suggest that COPD causes thinning of the RNFL, and severe retinal nerve fiber injury occurs more frequently in advanced COPD.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalAsian Journal of Ophthalmology
Volume15
Issue number3
Publication statusPublished - 2017

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Optical Coherence Tomography
Nerve Fibers
Chronic Obstructive Pulmonary Disease
Nose
Control Groups

Keywords

  • Chronic obstructive pulmonary disease
  • Glaucoma
  • Optic neuropathy
  • Optical coherence tomography
  • Retinal ganglion cells

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Retinal nerve fiber layer thickness in chronic obstructive pulmonary disease : An optical coherence tomography study. / Ghee, Yeap Thye; Mustapha, Mushawiahti; Harun, Roslan; Syed Zakaria, Syed Zulkifli; Che Hamzah, Jemaima; Harun, Hairul Nizam; Annuar, Faridah Hanom.

In: Asian Journal of Ophthalmology, Vol. 15, No. 3, 2017, p. 151-158.

Research output: Contribution to journalArticle

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abstract = "Background: To evaluate changes in the retinal nerve fiber layer (RNFL) thickness in patients with chronic obstructive pulmonary disease (COPD) using optical coherence tomography (OCT). Methods: In this case-controlled study, COPD subjects with various disease durations and severity were recruited. The standard global initiative for chronic obstructive lung disease (GOLD) criteria was used to determine the severity of COPD in the subjects. Healthy individuals were recruited as the control group. Peripapillary RNFL thickness was measured using spectral domain OCT. Results: Seventy-one eyes of 71 COPD patients and 71 eyes of healthy controls were examined. The RNFL in all quadrants and the average RNFL were significantly thinner in patients with COPD compared to the control group (p < 0.05). There were significant correlations between severity of COPD and RNFL thickness (p < 0.05) for the average RNFL (r = 0.831) and RNFL in all quadrants (superior RNFL r = 0.736, inferior RNFL r = 0.681, nasal RNFL r = 0.600, and temporal RNFL r = 0.353). Similar significant correlations were found between RNFL thickness and duration of COPD (p < 0.005) for the average RNFL(r = -0.674) and RNFL in all quadrants (superior r = -0.615, inferior r = -0.472, nasal r = -0.484, and temporal r = -0.323). The risk of having a thin RNFL (odds ratio) was 13-fold higher in patients with COPD. Conclusions: These results suggest that COPD causes thinning of the RNFL, and severe retinal nerve fiber injury occurs more frequently in advanced COPD.",
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T2 - An optical coherence tomography study

AU - Ghee, Yeap Thye

AU - Mustapha, Mushawiahti

AU - Harun, Roslan

AU - Syed Zakaria, Syed Zulkifli

AU - Che Hamzah, Jemaima

AU - Harun, Hairul Nizam

AU - Annuar, Faridah Hanom

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N2 - Background: To evaluate changes in the retinal nerve fiber layer (RNFL) thickness in patients with chronic obstructive pulmonary disease (COPD) using optical coherence tomography (OCT). Methods: In this case-controlled study, COPD subjects with various disease durations and severity were recruited. The standard global initiative for chronic obstructive lung disease (GOLD) criteria was used to determine the severity of COPD in the subjects. Healthy individuals were recruited as the control group. Peripapillary RNFL thickness was measured using spectral domain OCT. Results: Seventy-one eyes of 71 COPD patients and 71 eyes of healthy controls were examined. The RNFL in all quadrants and the average RNFL were significantly thinner in patients with COPD compared to the control group (p < 0.05). There were significant correlations between severity of COPD and RNFL thickness (p < 0.05) for the average RNFL (r = 0.831) and RNFL in all quadrants (superior RNFL r = 0.736, inferior RNFL r = 0.681, nasal RNFL r = 0.600, and temporal RNFL r = 0.353). Similar significant correlations were found between RNFL thickness and duration of COPD (p < 0.005) for the average RNFL(r = -0.674) and RNFL in all quadrants (superior r = -0.615, inferior r = -0.472, nasal r = -0.484, and temporal r = -0.323). The risk of having a thin RNFL (odds ratio) was 13-fold higher in patients with COPD. Conclusions: These results suggest that COPD causes thinning of the RNFL, and severe retinal nerve fiber injury occurs more frequently in advanced COPD.

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KW - Chronic obstructive pulmonary disease

KW - Glaucoma

KW - Optic neuropathy

KW - Optical coherence tomography

KW - Retinal ganglion cells

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