Resistance patterns of multidrug resistant acinetobacter baumannii in an ICU of a tertiary care hospital, Malaysia

Sivakami Janahiraman, Muhammad Nazri Aziz, Fan Kee Hoo, Hon Shen P’Ng, Yang Liang Boo, Vasudevan Ramachandran, Ahmad Fuad Shamsuddin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Backgrounds & Objective: Antimicrobial resistance is a major health problem worldwide in hospitals. The main contributing factors are exposures to broad-spectrum antimicrobials and cross-infections. Understanding the extent and type of antimicrobial use in tertiary care hospitals will aid in developing national antimicrobial stewardship priorities. Methods: In this study, we have analyzed the antimicrobial agents’ usage for acquisition of multidrug resistant using retrospective, cross-sectional, single-centre study in a multidisciplinary ICU at tertiary care hospital. Results: Acinetobacter baumannii (ACB) was isolated in various specimens from 662 patients. From these, 136 patients who were diagnosed with Ventilator-associated pneumonia (VAP) caused by ACB were included into the study. In our study, MDR strain accounts for 51% of all VAP cases caused by ACB. The development of ACB VAP were 10.5 + 6.4 days for MDR strains compared to susceptible organism (7.8 + 4.5 days) and had significantly longer ICU stay. Conclusion: The study concludes that prudent use of antimicrobial agents is important to reduce acquisition of MDR ACB.

Original languageEnglish
Pages (from-to)1383-1388
Number of pages6
JournalPakistan Journal of Medical Sciences
Volume31
Issue number6
DOIs
Publication statusPublished - 2015

Fingerprint

Acinetobacter baumannii
Malaysia
Multiple Drug Resistance
Tertiary Healthcare
Tertiary Care Centers
Ventilator-Associated Pneumonia
Anti-Infective Agents
Cross Infection

Keywords

  • Acinetobacter baumannii
  • Drug Resistance
  • Intensive Care Units
  • Malaysia
  • Ventilator-associated pneumonia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Janahiraman, S., Aziz, M. N., Hoo, F. K., P’Ng, H. S., Boo, Y. L., Ramachandran, V., & Shamsuddin, A. F. (2015). Resistance patterns of multidrug resistant acinetobacter baumannii in an ICU of a tertiary care hospital, Malaysia. Pakistan Journal of Medical Sciences, 31(6), 1383-1388. https://doi.org/10.12669/pjms.316.8445

Resistance patterns of multidrug resistant acinetobacter baumannii in an ICU of a tertiary care hospital, Malaysia. / Janahiraman, Sivakami; Aziz, Muhammad Nazri; Hoo, Fan Kee; P’Ng, Hon Shen; Boo, Yang Liang; Ramachandran, Vasudevan; Shamsuddin, Ahmad Fuad.

In: Pakistan Journal of Medical Sciences, Vol. 31, No. 6, 2015, p. 1383-1388.

Research output: Contribution to journalArticle

Janahiraman, S, Aziz, MN, Hoo, FK, P’Ng, HS, Boo, YL, Ramachandran, V & Shamsuddin, AF 2015, 'Resistance patterns of multidrug resistant acinetobacter baumannii in an ICU of a tertiary care hospital, Malaysia', Pakistan Journal of Medical Sciences, vol. 31, no. 6, pp. 1383-1388. https://doi.org/10.12669/pjms.316.8445
Janahiraman, Sivakami ; Aziz, Muhammad Nazri ; Hoo, Fan Kee ; P’Ng, Hon Shen ; Boo, Yang Liang ; Ramachandran, Vasudevan ; Shamsuddin, Ahmad Fuad. / Resistance patterns of multidrug resistant acinetobacter baumannii in an ICU of a tertiary care hospital, Malaysia. In: Pakistan Journal of Medical Sciences. 2015 ; Vol. 31, No. 6. pp. 1383-1388.
@article{b9ebe49740ed4869a139cb4787780e3f,
title = "Resistance patterns of multidrug resistant acinetobacter baumannii in an ICU of a tertiary care hospital, Malaysia",
abstract = "Backgrounds & Objective: Antimicrobial resistance is a major health problem worldwide in hospitals. The main contributing factors are exposures to broad-spectrum antimicrobials and cross-infections. Understanding the extent and type of antimicrobial use in tertiary care hospitals will aid in developing national antimicrobial stewardship priorities. Methods: In this study, we have analyzed the antimicrobial agents’ usage for acquisition of multidrug resistant using retrospective, cross-sectional, single-centre study in a multidisciplinary ICU at tertiary care hospital. Results: Acinetobacter baumannii (ACB) was isolated in various specimens from 662 patients. From these, 136 patients who were diagnosed with Ventilator-associated pneumonia (VAP) caused by ACB were included into the study. In our study, MDR strain accounts for 51{\%} of all VAP cases caused by ACB. The development of ACB VAP were 10.5 + 6.4 days for MDR strains compared to susceptible organism (7.8 + 4.5 days) and had significantly longer ICU stay. Conclusion: The study concludes that prudent use of antimicrobial agents is important to reduce acquisition of MDR ACB.",
keywords = "Acinetobacter baumannii, Drug Resistance, Intensive Care Units, Malaysia, Ventilator-associated pneumonia",
author = "Sivakami Janahiraman and Aziz, {Muhammad Nazri} and Hoo, {Fan Kee} and P’Ng, {Hon Shen} and Boo, {Yang Liang} and Vasudevan Ramachandran and Shamsuddin, {Ahmad Fuad}",
year = "2015",
doi = "10.12669/pjms.316.8445",
language = "English",
volume = "31",
pages = "1383--1388",
journal = "Pakistan Journal of Medical Sciences",
issn = "1682-024X",
publisher = "Professional Medical Publications",
number = "6",

}

TY - JOUR

T1 - Resistance patterns of multidrug resistant acinetobacter baumannii in an ICU of a tertiary care hospital, Malaysia

AU - Janahiraman, Sivakami

AU - Aziz, Muhammad Nazri

AU - Hoo, Fan Kee

AU - P’Ng, Hon Shen

AU - Boo, Yang Liang

AU - Ramachandran, Vasudevan

AU - Shamsuddin, Ahmad Fuad

PY - 2015

Y1 - 2015

N2 - Backgrounds & Objective: Antimicrobial resistance is a major health problem worldwide in hospitals. The main contributing factors are exposures to broad-spectrum antimicrobials and cross-infections. Understanding the extent and type of antimicrobial use in tertiary care hospitals will aid in developing national antimicrobial stewardship priorities. Methods: In this study, we have analyzed the antimicrobial agents’ usage for acquisition of multidrug resistant using retrospective, cross-sectional, single-centre study in a multidisciplinary ICU at tertiary care hospital. Results: Acinetobacter baumannii (ACB) was isolated in various specimens from 662 patients. From these, 136 patients who were diagnosed with Ventilator-associated pneumonia (VAP) caused by ACB were included into the study. In our study, MDR strain accounts for 51% of all VAP cases caused by ACB. The development of ACB VAP were 10.5 + 6.4 days for MDR strains compared to susceptible organism (7.8 + 4.5 days) and had significantly longer ICU stay. Conclusion: The study concludes that prudent use of antimicrobial agents is important to reduce acquisition of MDR ACB.

AB - Backgrounds & Objective: Antimicrobial resistance is a major health problem worldwide in hospitals. The main contributing factors are exposures to broad-spectrum antimicrobials and cross-infections. Understanding the extent and type of antimicrobial use in tertiary care hospitals will aid in developing national antimicrobial stewardship priorities. Methods: In this study, we have analyzed the antimicrobial agents’ usage for acquisition of multidrug resistant using retrospective, cross-sectional, single-centre study in a multidisciplinary ICU at tertiary care hospital. Results: Acinetobacter baumannii (ACB) was isolated in various specimens from 662 patients. From these, 136 patients who were diagnosed with Ventilator-associated pneumonia (VAP) caused by ACB were included into the study. In our study, MDR strain accounts for 51% of all VAP cases caused by ACB. The development of ACB VAP were 10.5 + 6.4 days for MDR strains compared to susceptible organism (7.8 + 4.5 days) and had significantly longer ICU stay. Conclusion: The study concludes that prudent use of antimicrobial agents is important to reduce acquisition of MDR ACB.

KW - Acinetobacter baumannii

KW - Drug Resistance

KW - Intensive Care Units

KW - Malaysia

KW - Ventilator-associated pneumonia

UR - http://www.scopus.com/inward/record.url?scp=84948968692&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948968692&partnerID=8YFLogxK

U2 - 10.12669/pjms.316.8445

DO - 10.12669/pjms.316.8445

M3 - Article

AN - SCOPUS:84948968692

VL - 31

SP - 1383

EP - 1388

JO - Pakistan Journal of Medical Sciences

JF - Pakistan Journal of Medical Sciences

SN - 1682-024X

IS - 6

ER -