Research open access fine-scale population structure of Malays in peninsular Malaysia and Singapore and implications for association studies

Boon Peng Hoh, Lian Deng, Mat Jusoh Julia-Ashazila, Zakaria Zuraihan, Ma'amor Nur-Hasnah, Ab Rajab Nur-Shafawati, Wan Isa Hatin, Endom Ismail, Bin Alwi Zilfalil, Yusoff Khalid, Shuhua Xu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Fine scale population structure of Malays - the major population in Malaysia, has not been well studied. This may have important implications for both evolutionary and medical studies. Here, we investigated the population sub-structure of Malay involving 431 samples collected from all states from peninsular Malaysia and Singapore. We identified two major clusters of individuals corresponding to the north and south peninsular Malaysia. On an even finer scale, the genetic coordinates of the geographical Malay populations are in correlation with the latitudes (R<sup>2</sup> = 0.3925; P = 0.029). This finding is further supported by the pairwise FST of Malay sub-populations, of which the north and south regions showed the highest differentiation (F<inf>ST [North-south]</inf> = 0.0011). The collective findings therefore suggest that population sub-structure of Malays are more heterogenous than previously expected even within a small geographical region, possibly due to factors like different genetic origins, geographical isolation, could result in spurious association as demonstrated in our analysis. We suggest that cautions should be taken during the stage of study design or interpreting the association signals in disease mapping studies which are expected to be conducted in Malay population in the near future.

Original languageEnglish
Article number16
JournalHuman Genomics
Volume9
DOIs
Publication statusPublished - 2015

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Malaysia
Singapore
Research
Population

Keywords

  • FST
  • Gwas simulation
  • Latitude-PC correlation
  • Malay
  • Population sub-structure

ASJC Scopus subject areas

  • Drug Discovery
  • Genetics
  • Molecular Biology
  • Molecular Medicine

Cite this

Research open access fine-scale population structure of Malays in peninsular Malaysia and Singapore and implications for association studies. / Hoh, Boon Peng; Deng, Lian; Julia-Ashazila, Mat Jusoh; Zuraihan, Zakaria; Nur-Hasnah, Ma'amor; Nur-Shafawati, Ab Rajab; Hatin, Wan Isa; Ismail, Endom; Zilfalil, Bin Alwi; Khalid, Yusoff; Xu, Shuhua.

In: Human Genomics, Vol. 9, 16, 2015.

Research output: Contribution to journalArticle

Hoh, BP, Deng, L, Julia-Ashazila, MJ, Zuraihan, Z, Nur-Hasnah, M, Nur-Shafawati, AR, Hatin, WI, Ismail, E, Zilfalil, BA, Khalid, Y & Xu, S 2015, 'Research open access fine-scale population structure of Malays in peninsular Malaysia and Singapore and implications for association studies', Human Genomics, vol. 9, 16. https://doi.org/10.1186/s40246-015-0039-x
Hoh, Boon Peng ; Deng, Lian ; Julia-Ashazila, Mat Jusoh ; Zuraihan, Zakaria ; Nur-Hasnah, Ma'amor ; Nur-Shafawati, Ab Rajab ; Hatin, Wan Isa ; Ismail, Endom ; Zilfalil, Bin Alwi ; Khalid, Yusoff ; Xu, Shuhua. / Research open access fine-scale population structure of Malays in peninsular Malaysia and Singapore and implications for association studies. In: Human Genomics. 2015 ; Vol. 9.
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