Repeatedly heated frying oil and high cholesterol diet are detrimental to the bone structure of ovariectomised rats

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Abstract

Oxidative stress and hypercholesterolemia have been shown to contribute to post-menopausal osteoporosis. In post-menopausal women, the use of repeatedly heated frying oils may aggravate oxidative stress condition while intake of high cholesterol diet may worsen hypercholesterolaemia. The aim of this study is to determine the combined effects of repeatedly heated (five times) frying oils (palm or soy oil) and high cholesterol diet on the bone structure of ovariectomised rats, an animal model of post-menopausal osteoporosis, by using bone histomorphometry. It was found that the addition of fresh or once-heated palm or soy oil into high cholesterol diet was able to protect ovariectomised rats bone from structural deterioration. However, when these oils were repeatedly heated, the protective effects were lost and the bone structures of the ovariectomised rats were either maintained by palm oil or worsen by soy oil.

Original languageEnglish
Pages (from-to)160-164
Number of pages5
JournalInternational Journal of Pharmacology
Volume3
Issue number2
Publication statusPublished - Mar 2007

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Oils
Cholesterol
Diet
Bone and Bones
Postmenopausal Osteoporosis
Hypercholesterolemia
Oxidative Stress
Animal Models

Keywords

  • Heated oils
  • Osteoporosis
  • Ovariectomy rats
  • Post-menopausal

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "Repeatedly heated frying oil and high cholesterol diet are detrimental to the bone structure of ovariectomised rats",
abstract = "Oxidative stress and hypercholesterolemia have been shown to contribute to post-menopausal osteoporosis. In post-menopausal women, the use of repeatedly heated frying oils may aggravate oxidative stress condition while intake of high cholesterol diet may worsen hypercholesterolaemia. The aim of this study is to determine the combined effects of repeatedly heated (five times) frying oils (palm or soy oil) and high cholesterol diet on the bone structure of ovariectomised rats, an animal model of post-menopausal osteoporosis, by using bone histomorphometry. It was found that the addition of fresh or once-heated palm or soy oil into high cholesterol diet was able to protect ovariectomised rats bone from structural deterioration. However, when these oils were repeatedly heated, the protective effects were lost and the bone structures of the ovariectomised rats were either maintained by palm oil or worsen by soy oil.",
keywords = "Heated oils, Osteoporosis, Ovariectomy rats, Post-menopausal",
author = "Shuid, {Ahmad Nazrun} and Chew, {C. M.} and Norazlina Mohamed and Kamsiah Jaarin and Soelaiman, {Ima Nirwana}",
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T1 - Repeatedly heated frying oil and high cholesterol diet are detrimental to the bone structure of ovariectomised rats

AU - Shuid, Ahmad Nazrun

AU - Chew, C. M.

AU - Mohamed, Norazlina

AU - Jaarin, Kamsiah

AU - Soelaiman, Ima Nirwana

PY - 2007/3

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N2 - Oxidative stress and hypercholesterolemia have been shown to contribute to post-menopausal osteoporosis. In post-menopausal women, the use of repeatedly heated frying oils may aggravate oxidative stress condition while intake of high cholesterol diet may worsen hypercholesterolaemia. The aim of this study is to determine the combined effects of repeatedly heated (five times) frying oils (palm or soy oil) and high cholesterol diet on the bone structure of ovariectomised rats, an animal model of post-menopausal osteoporosis, by using bone histomorphometry. It was found that the addition of fresh or once-heated palm or soy oil into high cholesterol diet was able to protect ovariectomised rats bone from structural deterioration. However, when these oils were repeatedly heated, the protective effects were lost and the bone structures of the ovariectomised rats were either maintained by palm oil or worsen by soy oil.

AB - Oxidative stress and hypercholesterolemia have been shown to contribute to post-menopausal osteoporosis. In post-menopausal women, the use of repeatedly heated frying oils may aggravate oxidative stress condition while intake of high cholesterol diet may worsen hypercholesterolaemia. The aim of this study is to determine the combined effects of repeatedly heated (five times) frying oils (palm or soy oil) and high cholesterol diet on the bone structure of ovariectomised rats, an animal model of post-menopausal osteoporosis, by using bone histomorphometry. It was found that the addition of fresh or once-heated palm or soy oil into high cholesterol diet was able to protect ovariectomised rats bone from structural deterioration. However, when these oils were repeatedly heated, the protective effects were lost and the bone structures of the ovariectomised rats were either maintained by palm oil or worsen by soy oil.

KW - Heated oils

KW - Osteoporosis

KW - Ovariectomy rats

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