Renoprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats

Kamisah Yusof, Shu Min Ang, Faizah Othman, Badlishah Sham Nurul-Iman, Qodriyah Mohd Saad

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Virgin coconut oil, rich in antioxidants, was shown to attenuate hypertension. This study aimed to investigate the effects of virgin coconut oil on blood pressure and related parameters in kidneys in rats fed with 5-times-heated palm oil (5HPO). Thirty-two male Sprague-Dawley rats were divided into 4 groups. Two groups were fed 5HPO (15%) diet and the second group was also given virgin coconut oil (1.42 mL/kg, oral) daily for 16 weeks. The other 2 groups were given basal diet without (control) and with virgin coconut oil. Systolic blood pressure was measured pre- and post-treatment. After 16 weeks, the rats were sacrificed and kidneys were harvested. Dietary 5HPO increased blood pressure, renal thiobarbituric acid reactive substance (TBARS), and nitric oxide contents, but decreased heme oxygenase activity. Virgin coconut oil prevented increase in 5HPO-induced blood pressure and renal nitric oxide content as well as the decrease in renal heme oxygenase activity. The virgin coconut oil also reduced the elevation of renal TBARS induced by the heated oil. However, neither dietary 5HPO nor virgin coconut oil affected renal histomorphometry. In conclusion, virgin coconut oil has a potential to reduce the development of hypertension and renal injury induced by dietary heated oil, possibly via its antioxidant protective effects on the kidneys.

Original languageEnglish
Pages (from-to)1033-1038
Number of pages6
JournalApplied Physiology, Nutrition and Metabolism
Volume41
Issue number10
DOIs
Publication statusPublished - 2016

Fingerprint

Diet
Kidney
Blood Pressure
Heme Oxygenase (Decyclizing)
Thiobarbituric Acid Reactive Substances
Nitric Oxide
Antioxidants
Unsaturated Dietary Fats
Renal Hypertension
palm oil
coconut oil
Sprague Dawley Rats
Oils
Hypertension
Wounds and Injuries

Keywords

  • Heme oxygenase
  • Hypertension
  • Kidney
  • Nitric oxide
  • Virgin coconut oil

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

Cite this

Renoprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats. / Yusof, Kamisah; Ang, Shu Min; Othman, Faizah; Nurul-Iman, Badlishah Sham; Mohd Saad, Qodriyah.

In: Applied Physiology, Nutrition and Metabolism, Vol. 41, No. 10, 2016, p. 1033-1038.

Research output: Contribution to journalArticle

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