Reliability of the ultrasound classification system of thyroid nodules in predicting malignancy

Farihah Abd Ghani, Nurismah Md Isa, Husyairi Harunarashid, Shahrun Niza Abdullah Suhaimi, Radhika Sridharan

Research output: Contribution to journalArticle

Abstract

Aim: This study aims to evaluate the reliability of the Ultrasound (U) Classification system in predicting thyroid malignancy by using pathology diagnosis as the reference standard. Materials and Methods: It was a cross sectional study carried out at Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Malaysia. Records of patients with focal thyroid nodules on ultrasound (US) for which US guided fine needle aspiration cytology (FNAC) was performed and pathology results were available, from January 2014 to May 2016 were selected for review. Correlation of the U Classification with pathology results was assessed. Sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, predictive value, negative predictive value and accuracy were calculated in a conservative and non-conservative method. The threshold for statistical performance was set at 0.05. Each sonographic feature was also compared with its pathology results. Results: A total of 91 patients with 104 nodules were eligible. 12 nodules out of 104 (11.5%) were malignant. The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, positive predictive value, negative predictive value and accuracy were 100%, 91.3%, 11.5, 0.0, 60%, 100% and 92.3%, and 100%, 91.4%, 11.7, 0.0, 78.6%, 100% and 93.5%, for the non-conservative and conservative method of calculations respectively. Conclusion: The U Classification is reliable in predicting thyroid malignancy. More evidence is nevertheless necessary for widespread adaptation and use.

Original languageEnglish
Pages (from-to)263-271
Number of pages9
JournalMedical Journal of Malaysia
Volume73
Issue number5
Publication statusPublished - 1 Oct 2018

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Thyroid Nodule
Pathology
Malaysia
Neoplasms
Thyroid Gland
Sensitivity and Specificity
Fine Needle Biopsy
Cell Biology
Cross-Sectional Studies

Keywords

  • Fine needle aspiration biopsy
  • Thyroid carcinoma
  • Thyroid nodules
  • Ultrasound

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Reliability of the ultrasound classification system of thyroid nodules in predicting malignancy. / Ghani, Farihah Abd; Md Isa, Nurismah; Harunarashid, Husyairi; Abdullah Suhaimi, Shahrun Niza; Sridharan, Radhika.

In: Medical Journal of Malaysia, Vol. 73, No. 5, 01.10.2018, p. 263-271.

Research output: Contribution to journalArticle

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