Reliability of the ultrasound classification system of thyroid nodules in predicting malignancy

Farihah Abd Ghani, Nurismah Md Isa, Husyairi Harunarashid, Shahrun Niza Abdullah Suhaimi, Radhika Sridharan

Research output: Contribution to journalArticle

Abstract

Aim: This study aims to evaluate the reliability of the Ultrasound (U) Classification system in predicting thyroid malignancy by using pathology diagnosis as the reference standard. Methods: It was a cross-sectional study carried out at Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Malaysia. Records of patients with focal thyroid nodules on ultrasound (US) for which US-guided fine needle aspiration cytology (FNAC) was performed and pathology results were available, from January 2014 to May 2016 were selected for review. Correlation of the U Classification with pathology results was assessed. Sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, predictive value, negative predictive value and accuracy were calculated in a conservative and non-conservative method. The threshold for statistical performance was set at 0.05. Each sonographic feature was also compared with its pathology results. Results: A total of 91 patients with 104 nodules were eligible. 12 nodules out of 104 (11.5%) were malignant. The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, positive predictive value, negative predictive value and accuracy were 100%, 91.3%, 11.5, 0.0, 60%, 100% and 92.3%, and 100%, 91.4%, 11.7%, 0.0, 78.6%, 100% and 93.5%, for the non-conservative and conservative method of calculations respectively. Conclusion: The U Classification is reliable in predicting thyroid malignancy. More evidence is nevertheless necessary for widespread adaptation and use.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalMedical Journal of Malaysia
Volume73
Issue number1
Publication statusPublished - 1 Feb 2018

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Thyroid Nodule
Pathology
Malaysia
Neoplasms
Thyroid Gland
Sensitivity and Specificity
Fine Needle Biopsy
Cell Biology
Cross-Sectional Studies

Keywords

  • Fine needle aspiration biopsy
  • Thyroid carcinoma
  • Thyroid nodules
  • Ultrasound

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Reliability of the ultrasound classification system of thyroid nodules in predicting malignancy. / Ghani, Farihah Abd; Md Isa, Nurismah; Harunarashid, Husyairi; Abdullah Suhaimi, Shahrun Niza; Sridharan, Radhika.

In: Medical Journal of Malaysia, Vol. 73, No. 1, 01.02.2018, p. 9-15.

Research output: Contribution to journalArticle

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