Relationships between dietary nutrients intake and lipid levels with functional MRI dorsolateral prefrontal cortex activation

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2 Citations (Scopus)

Abstract

Background: Dorsolateral prefrontal cortex (DLPFC) is a key node in the cognitive control network that supports working memory. DLPFC dysfunction is related to cognitive impairment. It has been suggested that dietary components and high-density lipoprotein cholesterol (HDL-C) play a vital role in brain health and cognitive function. Purpose: This study aimed to investigate the relationships between dietary nutrient intake and lipid levels with functional MRI (fMRI) brain activation in DLPFC among older adults with mild cognitive impairment. Participants and methods: A total of 15 community-dwelling older adults with mild cognitive impairment, aged ≥60 years, participated in this cross-sectional study at selected senior citizen clubs in Klang Valley, Malaysia. The 7-day recall Diet History Questionnaire was used to assess participants’ dietary nutrient intake. Fasting blood samples were also collected for lipid profile assessment. All participants performed N-back (0-and 1-back) working memory tasks during fMRI scanning. DLPFC (Brodmann’s areas 9 and 46, and inferior, middle, and superior frontal gyrus) was identified as a region of interest for analysis. Results: Positive associations were observed between dietary intake of energy, protein, cholesterol, vitamins B6 and B12, potassium, iron, phosphorus, magnesium, and HDL-C with DLPFC activation (P<0.05). Multivariate analysis showed that vitamin B6 intake, β=0.505, t (14)=3.29, P=0.023, and Digit Symbol score, β=0.413, t (14)=2.89, P=0.045; R2=0.748, were positively related to DLPFC activation. Conclusion: Increased vitamin B6 intake and cognitive processing speed were related to greater activation in the DLPFC region, which was responsible for working memory, executive function, attention, planning, and decision making. Further studies are needed to elucidate the mechanisms underlying the association.

Original languageEnglish
Pages (from-to)43-51
Number of pages9
JournalClinical Interventions in Aging
Volume14
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Prefrontal Cortex
Magnetic Resonance Imaging
Lipids
Food
Vitamin B 6
Short-Term Memory
HDL Cholesterol
Independent Living
Malaysia
Executive Function
Brain
Vitamin B 12
Energy Intake
Phosphorus
Magnesium
Cognition
Fasting
Decision Making
Potassium
Multivariate Analysis

Keywords

  • Brain activation
  • Fmri
  • HDL-C
  • Vitamin B6

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

@article{afc091c3aadc4b16a67e28eac8fb9201,
title = "Relationships between dietary nutrients intake and lipid levels with functional MRI dorsolateral prefrontal cortex activation",
abstract = "Background: Dorsolateral prefrontal cortex (DLPFC) is a key node in the cognitive control network that supports working memory. DLPFC dysfunction is related to cognitive impairment. It has been suggested that dietary components and high-density lipoprotein cholesterol (HDL-C) play a vital role in brain health and cognitive function. Purpose: This study aimed to investigate the relationships between dietary nutrient intake and lipid levels with functional MRI (fMRI) brain activation in DLPFC among older adults with mild cognitive impairment. Participants and methods: A total of 15 community-dwelling older adults with mild cognitive impairment, aged ≥60 years, participated in this cross-sectional study at selected senior citizen clubs in Klang Valley, Malaysia. The 7-day recall Diet History Questionnaire was used to assess participants’ dietary nutrient intake. Fasting blood samples were also collected for lipid profile assessment. All participants performed N-back (0-and 1-back) working memory tasks during fMRI scanning. DLPFC (Brodmann’s areas 9 and 46, and inferior, middle, and superior frontal gyrus) was identified as a region of interest for analysis. Results: Positive associations were observed between dietary intake of energy, protein, cholesterol, vitamins B6 and B12, potassium, iron, phosphorus, magnesium, and HDL-C with DLPFC activation (P<0.05). Multivariate analysis showed that vitamin B6 intake, β=0.505, t (14)=3.29, P=0.023, and Digit Symbol score, β=0.413, t (14)=2.89, P=0.045; R2=0.748, were positively related to DLPFC activation. Conclusion: Increased vitamin B6 intake and cognitive processing speed were related to greater activation in the DLPFC region, which was responsible for working memory, executive function, attention, planning, and decision making. Further studies are needed to elucidate the mechanisms underlying the association.",
keywords = "Brain activation, Fmri, HDL-C, Vitamin B6",
author = "Huijin Lau and Suzana Shahar and Mazlyfarina Mohamad and Rajab, {Nor Fadilah} and Yahya, {Hanis Mastura} and {Che Din}, Normah and {Abdul Hamid}, Hamzaini",
year = "2019",
month = "1",
day = "1",
doi = "10.2147/CIA.S183425",
language = "English",
volume = "14",
pages = "43--51",
journal = "Clinical Interventions in Aging",
issn = "1176-9092",
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T1 - Relationships between dietary nutrients intake and lipid levels with functional MRI dorsolateral prefrontal cortex activation

AU - Lau, Huijin

AU - Shahar, Suzana

AU - Mohamad, Mazlyfarina

AU - Rajab, Nor Fadilah

AU - Yahya, Hanis Mastura

AU - Che Din, Normah

AU - Abdul Hamid, Hamzaini

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Dorsolateral prefrontal cortex (DLPFC) is a key node in the cognitive control network that supports working memory. DLPFC dysfunction is related to cognitive impairment. It has been suggested that dietary components and high-density lipoprotein cholesterol (HDL-C) play a vital role in brain health and cognitive function. Purpose: This study aimed to investigate the relationships between dietary nutrient intake and lipid levels with functional MRI (fMRI) brain activation in DLPFC among older adults with mild cognitive impairment. Participants and methods: A total of 15 community-dwelling older adults with mild cognitive impairment, aged ≥60 years, participated in this cross-sectional study at selected senior citizen clubs in Klang Valley, Malaysia. The 7-day recall Diet History Questionnaire was used to assess participants’ dietary nutrient intake. Fasting blood samples were also collected for lipid profile assessment. All participants performed N-back (0-and 1-back) working memory tasks during fMRI scanning. DLPFC (Brodmann’s areas 9 and 46, and inferior, middle, and superior frontal gyrus) was identified as a region of interest for analysis. Results: Positive associations were observed between dietary intake of energy, protein, cholesterol, vitamins B6 and B12, potassium, iron, phosphorus, magnesium, and HDL-C with DLPFC activation (P<0.05). Multivariate analysis showed that vitamin B6 intake, β=0.505, t (14)=3.29, P=0.023, and Digit Symbol score, β=0.413, t (14)=2.89, P=0.045; R2=0.748, were positively related to DLPFC activation. Conclusion: Increased vitamin B6 intake and cognitive processing speed were related to greater activation in the DLPFC region, which was responsible for working memory, executive function, attention, planning, and decision making. Further studies are needed to elucidate the mechanisms underlying the association.

AB - Background: Dorsolateral prefrontal cortex (DLPFC) is a key node in the cognitive control network that supports working memory. DLPFC dysfunction is related to cognitive impairment. It has been suggested that dietary components and high-density lipoprotein cholesterol (HDL-C) play a vital role in brain health and cognitive function. Purpose: This study aimed to investigate the relationships between dietary nutrient intake and lipid levels with functional MRI (fMRI) brain activation in DLPFC among older adults with mild cognitive impairment. Participants and methods: A total of 15 community-dwelling older adults with mild cognitive impairment, aged ≥60 years, participated in this cross-sectional study at selected senior citizen clubs in Klang Valley, Malaysia. The 7-day recall Diet History Questionnaire was used to assess participants’ dietary nutrient intake. Fasting blood samples were also collected for lipid profile assessment. All participants performed N-back (0-and 1-back) working memory tasks during fMRI scanning. DLPFC (Brodmann’s areas 9 and 46, and inferior, middle, and superior frontal gyrus) was identified as a region of interest for analysis. Results: Positive associations were observed between dietary intake of energy, protein, cholesterol, vitamins B6 and B12, potassium, iron, phosphorus, magnesium, and HDL-C with DLPFC activation (P<0.05). Multivariate analysis showed that vitamin B6 intake, β=0.505, t (14)=3.29, P=0.023, and Digit Symbol score, β=0.413, t (14)=2.89, P=0.045; R2=0.748, were positively related to DLPFC activation. Conclusion: Increased vitamin B6 intake and cognitive processing speed were related to greater activation in the DLPFC region, which was responsible for working memory, executive function, attention, planning, and decision making. Further studies are needed to elucidate the mechanisms underlying the association.

KW - Brain activation

KW - Fmri

KW - HDL-C

KW - Vitamin B6

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