Relationship between selenium and breast cancer

A case-control study in the Klang Valley

Suzana Shahar, B. G. Cham, Ahmad Rohi Ghazali, R. Mohd Rizal, M. N. Fairulnizal, H. Normah, A. Fatimah

Research output: Contribution to journalArticle

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Abstract

Introduction: The purpose of this study was to assess the relationship between selenium status and intake among breast cancer patients from the Klang Valley. Methods: 64 cases and 127 controls were matched for age (range 30-65 years) and ethnicity, with an 80 percent study power. Subjects were interviewed to obtain information on their habitual dietary intakes, demographic data and medical history. Selenium status was determined from toenail and hair analysis using an inductively coupled plasma mass spectrometer. Results: The nutrient analysis showed that total energy and protein intake was significantly higher among controls (1,403 +/- 367 kcal/day, 75.6 +/-33.2 g/day) as compared to cases (1,273 +/- 295 kcal/day, 60.9 +/- 19.1 g/day) (p-value is less than 0.05). The selenium intake among cases (78.47 +/- 25.34 μg/day) was significantly lower than the controls (89.34 +/- 36.85 μg/day) (p-value is less than 0.05). Breast cancer risk decreased with the increasing quartiles of selenium intake, with odds ratios (95 percent confidence interval) of 2.95 (1.22-7.12), 2.17 (1.13-4.19) and 1.71 (0.84-3.52), respectively. However, the association diminished after adjustment for confounding factors. Selenium in hair did not differ among cases and controls, but selenium status in the nails of controls was significantly higher as compared to cases (p-value is less than 0.05). Breast cancer risk decreased with the increasing quartiles of toenail selenium status as measured in the toenail and hair. Conclusion: Selenium intake and status was associated with breast cancer risk. Thus, it is essential for Malaysian women to achieve a good selenium status by consuming good food sources of selenium as a chemopreventive agent.

Original languageEnglish
Pages (from-to)265-269
Number of pages5
JournalSingapore Medical Journal
Volume50
Issue number3
Publication statusPublished - Mar 2009

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Selenium
Case-Control Studies
Breast Neoplasms
Nails
Hair
Food
Energy Intake
Odds Ratio
Demography
Confidence Intervals

Keywords

  • Breast cancer
  • Cancer risk factors
  • Case-control studies
  • Chemopreventive agent
  • Selenium
  • Selenium intake

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Shahar, S., Cham, B. G., Ghazali, A. R., Mohd Rizal, R., Fairulnizal, M. N., Normah, H., & Fatimah, A. (2009). Relationship between selenium and breast cancer: A case-control study in the Klang Valley. Singapore Medical Journal, 50(3), 265-269.

Relationship between selenium and breast cancer : A case-control study in the Klang Valley. / Shahar, Suzana; Cham, B. G.; Ghazali, Ahmad Rohi; Mohd Rizal, R.; Fairulnizal, M. N.; Normah, H.; Fatimah, A.

In: Singapore Medical Journal, Vol. 50, No. 3, 03.2009, p. 265-269.

Research output: Contribution to journalArticle

Shahar, S, Cham, BG, Ghazali, AR, Mohd Rizal, R, Fairulnizal, MN, Normah, H & Fatimah, A 2009, 'Relationship between selenium and breast cancer: A case-control study in the Klang Valley', Singapore Medical Journal, vol. 50, no. 3, pp. 265-269.
Shahar, Suzana ; Cham, B. G. ; Ghazali, Ahmad Rohi ; Mohd Rizal, R. ; Fairulnizal, M. N. ; Normah, H. ; Fatimah, A. / Relationship between selenium and breast cancer : A case-control study in the Klang Valley. In: Singapore Medical Journal. 2009 ; Vol. 50, No. 3. pp. 265-269.
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AB - Introduction: The purpose of this study was to assess the relationship between selenium status and intake among breast cancer patients from the Klang Valley. Methods: 64 cases and 127 controls were matched for age (range 30-65 years) and ethnicity, with an 80 percent study power. Subjects were interviewed to obtain information on their habitual dietary intakes, demographic data and medical history. Selenium status was determined from toenail and hair analysis using an inductively coupled plasma mass spectrometer. Results: The nutrient analysis showed that total energy and protein intake was significantly higher among controls (1,403 +/- 367 kcal/day, 75.6 +/-33.2 g/day) as compared to cases (1,273 +/- 295 kcal/day, 60.9 +/- 19.1 g/day) (p-value is less than 0.05). The selenium intake among cases (78.47 +/- 25.34 μg/day) was significantly lower than the controls (89.34 +/- 36.85 μg/day) (p-value is less than 0.05). Breast cancer risk decreased with the increasing quartiles of selenium intake, with odds ratios (95 percent confidence interval) of 2.95 (1.22-7.12), 2.17 (1.13-4.19) and 1.71 (0.84-3.52), respectively. However, the association diminished after adjustment for confounding factors. Selenium in hair did not differ among cases and controls, but selenium status in the nails of controls was significantly higher as compared to cases (p-value is less than 0.05). Breast cancer risk decreased with the increasing quartiles of toenail selenium status as measured in the toenail and hair. Conclusion: Selenium intake and status was associated with breast cancer risk. Thus, it is essential for Malaysian women to achieve a good selenium status by consuming good food sources of selenium as a chemopreventive agent.

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