Relationship between head growth and neurodevelopmental outcome of Malaysian very low birthweight infants during the 1st year of life

L. C. Ong, N. Y. Boo, V. Chandran, Siti Zamratol Mai Sarah Mukari, L. Allison, S. L. Teoh, M. K. Nyein, M. S. Lye

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Abstract

A prospective study was carried out to (i) compare head growth patterns of 103 very low birthweight (VLBW, < 1500 g) Malaysian infants and 98 normal birthweight (NBW, 2500-< 4500 g) controls during the 1st year of life; and (ii) examine the relationship between neurodevelopmental outcome at 1 year of age and occipito-frontal head circumferences (OFC) at birth and at 1 year of age in VLBW babies. When compared with those of NBW infants at birth, mid-infancy and 1 year of age, the mean OFC ratios (observed/expected OFC at 50th percentile) of VLBW infants were significantly lower (p < 0.001). Small-for-gestational-age (SGA) VLBW babies had significantly lower mean OFC ratios than their appropriate-for-gestational-age (AGA) VLBW counterparts at birth (p < 0.001), but this difference was no longer seen at mid-infancy or at 1 year of age. Logistic regression analysis showed that abnormal late neonatal cranial ultrasound findings (odds ratio 8.5, 95% confidence interval 4.12-22.07; p < 0.001) and each additional day of oxygen therapy (odds ratio 1.15, 95% confidence interval 1.00-4.45; p = 0.045) were significant risk factors associated with neurodevelopmental disability at 1 year of age, while mean OFC ratios at birth or at 1 year of age were not. Poor postnatal head growth per se did not predict disability, but probably reflected the consequences of 'brain injury' as evidenced by abnormal brain scans.

Original languageEnglish
Pages (from-to)209-216
Number of pages8
JournalAnnals of Tropical Paediatrics
Volume17
Issue number3
Publication statusPublished - Sep 1997

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Head
Growth
Parturition
Gestational Age
Odds Ratio
Confidence Intervals
Brain Injuries
Logistic Models
Regression Analysis
Prospective Studies
Oxygen
Brain
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Relationship between head growth and neurodevelopmental outcome of Malaysian very low birthweight infants during the 1st year of life. / Ong, L. C.; Boo, N. Y.; Chandran, V.; Mukari, Siti Zamratol Mai Sarah; Allison, L.; Teoh, S. L.; Nyein, M. K.; Lye, M. S.

In: Annals of Tropical Paediatrics, Vol. 17, No. 3, 09.1997, p. 209-216.

Research output: Contribution to journalArticle

Ong, L. C. ; Boo, N. Y. ; Chandran, V. ; Mukari, Siti Zamratol Mai Sarah ; Allison, L. ; Teoh, S. L. ; Nyein, M. K. ; Lye, M. S. / Relationship between head growth and neurodevelopmental outcome of Malaysian very low birthweight infants during the 1st year of life. In: Annals of Tropical Paediatrics. 1997 ; Vol. 17, No. 3. pp. 209-216.
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