Relapsed Hodgkin's disease presenting as a right knee swelling

Leong Chooi Fun, P. Y. Soo, S Fadilah S. Abdul Wahid, Soon Keng Cheong

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 49 year-old Indian housewife was diagnosed with Hodgkin's disease in 1995. She was given combination chemotherapy comprising Chlorambucil, Vincristine, Procarbazine and Prednisolone. Unfortunately she defaulted after two courses of chemotherapy. One year later, she developed progressive right knee swelling and pain, associated with loss of appetite, loss of weight, intermittent fever, night sweats and pruritus. The right knee swelling measured 15cm x 20cm and was warm and tender. A plain radiograph of the right knee revealed osteolytic lesions at the distal end of the right femur and the proximal ends of the right tibia and fibula, associated with gross periosteal reaction and soft tissue swelling. Apart from left cervical lymphoadenopathy, examination of other systems was unremarkable. Pelvic bone marrow biopsy was inconclusive. An open biopsy of the lower end of the right femur was consistent with Hodgkin's disease. She was given salvage combination therapy comprising Chlorambucil, Vincristine, Procarbazine, Prednisolone, Doxorubicin, Bleomycin and Vinblastine. She tolerated the treatment well and responded with significant reduction in the swelling and pain of the right knee. Unfortunately, she again defaulted treatment after 2 courses of chemotherapy. This case illustrates an unusual presentation of Hodgkin's disease in relapse.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalMedical Journal of Malaysia
Volume58
Issue number1
Publication statusPublished - Mar 2003

Fingerprint

Hodgkin Disease
Knee
Procarbazine
Chlorambucil
Vincristine
Prednisolone
Femur
Pelvic Bones
Biopsy
Drug Therapy
Pain
Salvage Therapy
Fibula
Vinblastine
Sweat
Bleomycin
Appetite
Pruritus
Combination Drug Therapy
Tibia

Keywords

  • Relapsed Hodgkin's Disease
  • Right Knee Swelling

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Relapsed Hodgkin's disease presenting as a right knee swelling. / Chooi Fun, Leong; Soo, P. Y.; S. Abdul Wahid, S Fadilah; Cheong, Soon Keng.

In: Medical Journal of Malaysia, Vol. 58, No. 1, 03.2003, p. 131-134.

Research output: Contribution to journalArticle

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