Relapsed acute lymphoblastic leukemia presenting as optic neuritis

S Fadilah S. Abdul Wahid, Raymond Azman Ali, S. K. Cheong, A. Faridah

Research output: Contribution to journalArticle

Abstract

Leukemic infiltration of the optic nerve is rare [1]. [Camera, A., Piccirillo, G., Tranfa, F., Rosa, N., Frigeri, F., Martinelli, V., Rotoloi, B. (1993) "Optic nerve involvement in acute lymphoblastic leukemia", Leuk. Lymph. 11, 153-155]. Radiotherapy should be given urgently to all patients with optic nerve infiltrate to restore their vision [2]. [Rosenthal, A. (1983) "Ocular manifestation of leukemia", Ophthalmology 90, 899-905]. We report a case of a unilateral optic nerve relapse 7 months after diagnosis of acute lymphoblastic leukemia (ALL) in a 17-year-old boy who had been off treatment for 6 weeks. The ocular symptoms was initially diagnosed as primary optic neuritis and treated with corticosteroids resulting in temporary clinical recovery. Radiation therapy for ocular leukemia that was commenced 2 months after the onset of symptoms failed to reverse the visual loss. The lack of a reliable and effective tool to diagnose ocular leukemia at an early stage has resulted in significant treatment delay and poor visual outcome.

Original languageEnglish
Pages (from-to)267-269
Number of pages3
JournalHematology
Volume6
Issue number4
Publication statusPublished - 2001

Fingerprint

Optic Neuritis
Optic Nerve
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Eye Manifestations
Radiotherapy
Leukemic Infiltration
Lymph
Ophthalmology
Adrenal Cortex Hormones
Recurrence
Therapeutics

Keywords

  • Acute lymphoblastic leukemia
  • Acute visual loss
  • Fine-needle aspiration (FNA)
  • Ocular leukemia
  • Optic neuritis

ASJC Scopus subject areas

  • Hematology

Cite this

Relapsed acute lymphoblastic leukemia presenting as optic neuritis. / S. Abdul Wahid, S Fadilah; Ali, Raymond Azman; Cheong, S. K.; Faridah, A.

In: Hematology, Vol. 6, No. 4, 2001, p. 267-269.

Research output: Contribution to journalArticle

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