Recovery of succinic acid from fermentation broth by forward osmosis-assisted crystallization process

Jeng Yih Law, Abdul Wahab Mohammad, Zhao Kang Tee, Nadiah Khairul Zaman, Jamaliah Md Jahim, Jude Santanaraj, Sajab Mohd Shaiful

Research output: Contribution to journalArticle

Abstract

In this study, osmotically driven forward osmosis (FO) was employed prior to crystallization process in the downstream recovery of bio-based succinic acid. The fermentation broth containing succinic acid was initially pretreated using activated carbon. Powdered activated carbon (PAC) showed its effectiveness for glucose, formic acid, and color removal while succinic acid concentration remained unaffected. The untreated and treated fermentation broths were then concentrated using the FO process. FO exhibited a remarkable enhancement of concentration factor (CF) by 3.9-fold for the treated broth, thus resulting in a final succinic acid concentration of 111.26 g/L. By contrast, higher flux loss and lower CF were observed for untreated broth, mainly due to the adverse effect of severe membrane fouling and cake layer formation. Succinic acid crystals were then successfully recovered from the FO-concentrated broth in the final crystallization step. The purity and yield of succinic acid crystals were 90.52% and 67.09%, respectively for treated broth. This work demonstrated the development of a feasible FO-crystallization process for the downstream recovery of bio-based succinic acid. The findings have important implications for practical applications of FO technology in the bioprocess industries.

Original languageEnglish
Pages (from-to)139-151
Number of pages13
JournalJournal of Membrane Science
Volume583
DOIs
Publication statusPublished - 1 Aug 2019

Fingerprint

broths
Osmosis
fermentation
osmosis
Succinic Acid
Crystallization
Fermentation
recovery
crystallization
Recovery
acids
Acids
formic acid
activated carbon
Activated carbon
Carbon
Membrane fouling
Crystals
fouling
Formic acid

Keywords

  • Activated carbon
  • Crystallization
  • Fermentation broth
  • Forward osmosis
  • Succinic acid

ASJC Scopus subject areas

  • Biochemistry
  • Materials Science(all)
  • Physical and Theoretical Chemistry
  • Filtration and Separation

Cite this

Recovery of succinic acid from fermentation broth by forward osmosis-assisted crystallization process. / Law, Jeng Yih; Mohammad, Abdul Wahab; Tee, Zhao Kang; Zaman, Nadiah Khairul; Md Jahim, Jamaliah; Santanaraj, Jude; Mohd Shaiful, Sajab.

In: Journal of Membrane Science, Vol. 583, 01.08.2019, p. 139-151.

Research output: Contribution to journalArticle

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