Recent updates on treatment of ocular microbial infections by stem cell therapy

A review

Seoh Wei Teh, Pooi Ling Mok, Munirah Abd Rashid, Mae-Lynn Catherine Bastion, Normala Ibrahim, Akon Higuchi, Kadarkarai Murugan, Rajan Mariappan, Suresh Kumar Subbiah

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Ocular microbial infection has emerged as a major public health crisis during the past two decades. A variety of causative agents can cause ocular microbial infections; which are characterized by persistent and destructive inflammation of the ocular tissue; progressive visual disturbance; and may result in loss of visual function in patients if early and effective treatments are not received. The conventional therapeutic approaches to treat vision impairment and blindness resulting from microbial infections involve antimicrobial therapy to eliminate the offending pathogens or in severe cases; by surgical methods and retinal prosthesis replacing of the infected area. In cases where there is concurrent inflammation, once infection is controlled, anti-inflammatory agents are indicated to reduce ocular damage from inflammation which ensues. Despite advances in medical research; progress in the control of ocular microbial infections remains slow. The varying level of ocular tissue recovery in individuals and the incomplete visual functional restoration indicate the chief limitations of current strategies. The development of a more extensive therapy is needed to help in healing to regain vision in patients. Stem cells are multipotent stromal cells that can give rise to a vast variety of cell types following proper differentiation protocol. Stem cell therapy shows promise in reducing inflammation and repairing tissue damage on the eye caused by microbial infections by its ability to modulate immune response and promote tissue regeneration. This article reviews a selected list of common infectious agents affecting the eye; which include fungi; viruses; parasites and bacteria with the aim of discussing the current antimicrobial treatments and the associated therapeutic challenges. We also provide recent updates of the advances in stem cells studies on sepsis therapy as a suggestion of optimum treatment regime for ocular microbial infections.

Original languageEnglish
Article number558
JournalInternational Journal of Molecular Sciences
Volume19
Issue number2
DOIs
Publication statusPublished - 13 Feb 2018
Externally publishedYes

Fingerprint

Eye Infections
stem cells
infectious diseases
Cell- and Tissue-Based Therapy
Stem cells
therapy
Stem Cells
Tissue
Tissue regeneration
Regain
Public health
Pathogens
Inflammation
Fungi
Viruses
Restoration
Bacteria
Anti-Inflammatory Agents
Therapeutics
Recovery

Keywords

  • Endophthalmitis
  • Inflammation
  • Ocular microbial infections
  • Stem cells
  • Tissue regeneration

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Recent updates on treatment of ocular microbial infections by stem cell therapy : A review. / Teh, Seoh Wei; Mok, Pooi Ling; Rashid, Munirah Abd; Bastion, Mae-Lynn Catherine; Ibrahim, Normala; Higuchi, Akon; Murugan, Kadarkarai; Mariappan, Rajan; Subbiah, Suresh Kumar.

In: International Journal of Molecular Sciences, Vol. 19, No. 2, 558, 13.02.2018.

Research output: Contribution to journalReview article

Teh, SW, Mok, PL, Rashid, MA, Bastion, M-LC, Ibrahim, N, Higuchi, A, Murugan, K, Mariappan, R & Subbiah, SK 2018, 'Recent updates on treatment of ocular microbial infections by stem cell therapy: A review', International Journal of Molecular Sciences, vol. 19, no. 2, 558. https://doi.org/10.3390/ijms19020558
Teh, Seoh Wei ; Mok, Pooi Ling ; Rashid, Munirah Abd ; Bastion, Mae-Lynn Catherine ; Ibrahim, Normala ; Higuchi, Akon ; Murugan, Kadarkarai ; Mariappan, Rajan ; Subbiah, Suresh Kumar. / Recent updates on treatment of ocular microbial infections by stem cell therapy : A review. In: International Journal of Molecular Sciences. 2018 ; Vol. 19, No. 2.
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