Recent updates on the phytochemistry, pharmacological, and toxicological activities of Zingiber zerumbet (L.) roscoe ex Sm.

Md Areeful Haque, Ibrahim Jantan

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Background: Zingiber zerumbet (L.) Roscoe ex Sm. (family, Zingiberaceae) is a potent medicinal herb widely known as shampoo ginger and its rhizome is used in numerous ethnomedicinal applications including antipyretic, anti-inflammatory, antibacterial, anti-diarrheal, antidiabetics, carminative, and diuretic. The aim of this review was to bring together all the scientific updates on the phytochemistry and pharmacological activities of this herb, including their toxicological studies, and critically analyzed the outcomes to provide directions for future research on the herb as potential source of bioactive metabolites for pharmaceutical and nutraceutical applications. Methods: A structured electronic search on worldwide accepted scientific databases (Web of Science, PubMed, Google Scholar, Science Direct, SciFinder, Wiley Online Library) was carried out to compile the relevant information. Some information was obtained from books and database on medicinal plants used in various countries. Results: About 60 metabolites, mainly polyphenols, and terpenoids have been isolated and identified. However, most of the reported pharmacological studies were based on crude extracts, and only a few of those isolated metabolites, particularly zerumbone have been investigated for biological and pharmacological activities. Many of the mechanistic studies to understand the pharmacological effects of the plant are limited by many considerations with regard to design, experimentation and interpretation. Conclusion: The bioactive metabolites should be further investigated on their safety and more elaborate preclinical studies before clinical trials can be undertaken.

Original languageEnglish
Pages (from-to)696-720
Number of pages25
JournalCurrent Pharmaceutical Biotechnology
Volume18
Issue number9
DOIs
Publication statusPublished - 1 Jan 2017

Fingerprint

Toxicology
Pharmacology
Medicinal Plants
Zingiberaceae
Databases
Ginger
Antipyretics
Rhizome
Terpenes
Polyphenols
Dietary Supplements
Complex Mixtures
Diuretics
Hypoglycemic Agents
PubMed
Libraries
Anti-Inflammatory Agents
Clinical Trials
Safety
Pharmaceutical Preparations

Keywords

  • Pharmacological effects
  • Phytochemicals
  • Rhizome
  • Toxicological effects
  • Zerumbone
  • Zingiber zerumbet

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

Cite this

Recent updates on the phytochemistry, pharmacological, and toxicological activities of Zingiber zerumbet (L.) roscoe ex Sm. / Haque, Md Areeful; Jantan, Ibrahim.

In: Current Pharmaceutical Biotechnology, Vol. 18, No. 9, 01.01.2017, p. 696-720.

Research output: Contribution to journalReview article

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