Recent progress in adjuvant discovery for peptide-based subunit vaccines

Fazren Azmi, Abdullah Al Hadi Ahmad Fuaad, Mariusz Skwarczynski, Istvan Toth

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Peptide-based subunit vaccines are of great interest in modern immunotherapy as they are safe, easy to produce and well defined. However, peptide antigens produce a relatively weak immune response, and thus require the use of immunostimulants (adjuvants) for optimal efficacy. Developing a safe and effective adjuvant remains a challenge for peptide-based vaccine design. Recent advances in immunology have allowed researchers to have a better understanding of the immunological implication of related diseases, which facilitates more rational design of adjuvant systems. Understanding the molecular structure of the adjuvants allows the establishment of their structure-activity relationships which is useful for the development of next-generation adjuvants. This review summarizes the current state of adjuvants development in the field of synthetic peptide-based vaccines. The structural, chemical and biological properties of adjuvants associated with their immunomodulatory effects are discussed.

Original languageEnglish
Pages (from-to)778-796
Number of pages19
JournalHuman Vaccines and Immunotherapeutics
Volume10
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Subunit Vaccines
Peptides
Immunologic Adjuvants
Synthetic Vaccines
Structure-Activity Relationship
Allergy and Immunology
Molecular Structure
Immunotherapy
Research Personnel
Antigens

Keywords

  • Adjuvant
  • Dendritic cell
  • Peptide vaccine
  • Toll-like receptor
  • Vaccine delivery

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Recent progress in adjuvant discovery for peptide-based subunit vaccines. / Azmi, Fazren; Fuaad, Abdullah Al Hadi Ahmad; Skwarczynski, Mariusz; Toth, Istvan.

In: Human Vaccines and Immunotherapeutics, Vol. 10, No. 3, 2014, p. 778-796.

Research output: Contribution to journalArticle

Azmi, Fazren ; Fuaad, Abdullah Al Hadi Ahmad ; Skwarczynski, Mariusz ; Toth, Istvan. / Recent progress in adjuvant discovery for peptide-based subunit vaccines. In: Human Vaccines and Immunotherapeutics. 2014 ; Vol. 10, No. 3. pp. 778-796.
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