Recent developments on phenstatins as potent antimitotic agents

Xing Chen, Shi Meng Wang, Gajjela Bharath Kumar, Grant A.L. Bare, Jing Leng, Bukhari Syed Nasir Abbas, Hua Li Qin

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Background: Phenstatin and their derivatives display remarkable antiproliferative activity toward a wide variety of preclinical tumor models. Structural simplicity and excellent stability of phenstatins offer a stimulating premise for developing various derivatives with profound antimitotic activity and excellent cytotoxicity. Objective: To do analysis of literature that phenstatins derivatives inhibit tubulin polymerization through their interaction at the colchicine binding site of microtubules and arrest the G2/M phase of the cell cycle. In addition, phenstatin derivatives are undergoing clinical evaluation as vascular targeting/disrupting agents and also exhibit direct antiangiogenic properties. Methods: An organised well designed and appropriately managed search of bibliographic databases for peer-reviewed research literature using a focused review question and inclusion/ exclusion criteria has been done for this article. Conclusion: In this review article, the synthesis and structure-activity relationships of phenstatin and a wide number of their reported analogues with modifications to ring A, ring B, and to the keto position are discussed in the perspective of medicinal chemistry with proper conclusion.

Original languageEnglish
Pages (from-to)2329-2352
Number of pages24
JournalCurrent Medicinal Chemistry
Volume25
Issue number20
DOIs
Publication statusPublished - 1 Jan 2018
Externally publishedYes

Fingerprint

Bibliographic Databases
M Phase Cell Cycle Checkpoints
Antimitotic Agents
Pharmaceutical Chemistry
G2 Phase
Colchicine
Structure-Activity Relationship
Tubulin
Microtubules
Polymerization
Blood Vessels
Binding Sites
Derivatives
Research
Neoplasms
Cytotoxicity
Tumors
Cells

Keywords

  • Antimitotic activity
  • Colchicine binding site
  • Cytotoxic activity
  • Phenstatins
  • Structure-activity relationship
  • Tubulin polymerization inhibition

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Recent developments on phenstatins as potent antimitotic agents. / Chen, Xing; Wang, Shi Meng; Kumar, Gajjela Bharath; Bare, Grant A.L.; Leng, Jing; Syed Nasir Abbas, Bukhari; Qin, Hua Li.

In: Current Medicinal Chemistry, Vol. 25, No. 20, 01.01.2018, p. 2329-2352.

Research output: Contribution to journalReview article

Chen, Xing ; Wang, Shi Meng ; Kumar, Gajjela Bharath ; Bare, Grant A.L. ; Leng, Jing ; Syed Nasir Abbas, Bukhari ; Qin, Hua Li. / Recent developments on phenstatins as potent antimitotic agents. In: Current Medicinal Chemistry. 2018 ; Vol. 25, No. 20. pp. 2329-2352.
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AU - Syed Nasir Abbas, Bukhari

AU - Qin, Hua Li

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