Recent advances in the role of supramolecular hydrogels in drug delivery

Mohd Cairul Iqbal Mohd Amin, Naveed Ahmad, Manisha Pandey, Muhammad Mustafa Abeer, Najwa Mohamad

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Introduction: Supramolecular hydrogels, formed by noncovalent crosslinking of polymeric chains in water, constitute an interesting class of materials that can be developed specifically for drug delivery and biomedical applications. The biocompatibility, stimuli responsiveness to various external factors, and powerful functionalization capacity of these polymeric networks make them attractive candidates for novel advanced dosage form design.Areas covered: This review summarizes the significance of supramolecular hydrogels in various biomedical and drug delivery applications. The recent advancement of these hydrogels as potential advanced drug delivery systems (for gene, protein, anticancer and other drugs) is discussed. The importance of these hydrogels in biomedical applications, particularly in tissue engineering, biosensing, cell-culture research and wound treatment is briefly described.Expert opinion: The use of supramolecular hydrogels in drug delivery is still in very early stages. However, the potential of such a system is undeniably important and very promising. A number of recent studies have been conducted, which mainly focus on the use of cyclodextrin-based host-guest complex as well as other supramolecular motifs to form supramolecular hydrogels for delivery of various classes of drugs, therapeutic agents, proteins and genes. However, there are still plenty of opportunities for further development in this area for drug delivery and other biomedical applications.

Original languageEnglish
Pages (from-to)1149-1161
Number of pages13
JournalExpert Opinion on Drug Delivery
Volume12
Issue number7
DOIs
Publication statusPublished - 1 Jul 2015

Fingerprint

Hydrogels
Pharmaceutical Preparations
Dosage Forms
Cyclodextrins
Expert Testimony
Drug Delivery Systems
Tissue Engineering
Proteins
Cell Culture Techniques
Water
Wounds and Injuries
Therapeutics
Research

Keywords

  • Advanced drug delivery systems
  • Cyclodextrin
  • Drug delivery
  • Host-guest inclusion complex
  • Supramolecular hydrogels

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Recent advances in the role of supramolecular hydrogels in drug delivery. / Mohd Amin, Mohd Cairul Iqbal; Ahmad, Naveed; Pandey, Manisha; Abeer, Muhammad Mustafa; Mohamad, Najwa.

In: Expert Opinion on Drug Delivery, Vol. 12, No. 7, 01.07.2015, p. 1149-1161.

Research output: Contribution to journalArticle

Mohd Amin, Mohd Cairul Iqbal ; Ahmad, Naveed ; Pandey, Manisha ; Abeer, Muhammad Mustafa ; Mohamad, Najwa. / Recent advances in the role of supramolecular hydrogels in drug delivery. In: Expert Opinion on Drug Delivery. 2015 ; Vol. 12, No. 7. pp. 1149-1161.
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