Recent advances in the design, development, and targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy

Muhammad Wahab Amjad, Prashant Kesharwani, Mohd Cairul Iqbal Mohd Amin, Arun K. Iyer

Research output: Contribution to journalReview article

53 Citations (Scopus)

Abstract

Small interfering RNA (siRNA) is a relatively novel nucleic acid-based therapy to treat diseases such as cancer. Nevertheless, substantial obstacles to its clinical applications have been reported, such as low cellular uptake, immunogenicity, off-target effects, and instability in physiological environments. The design of appropriate delivery vehicles capable of transporting siRNA to target cells has been pursued. Nanoparticles are extensively studied for the delivery of siRNA. Among the various nanocarriers, polymeric micelles have recently gained strong interest. Polymeric micelles of average nanometer size are straightforward to design and modify. Hydrophilic groups incorporated in the polymeric micelles can extend in vivo half-life of siRNA to ensure adequate accumulation in tumors, be exchanged for cations that electrostatically interact with siRNA, and be coupled to various ligands for cell-specific targeting. The polymeric micelle core provides stability and serves as a loading dock for drugs. In this review, the different types of polymers used, the design and characterization of polymeric micelles for siRNA delivery, and the established polymeric micelle targeting mechanisms are discussed.

Original languageEnglish
Pages (from-to)154-181
Number of pages28
JournalProgress in Polymer Science
Volume64
DOIs
Publication statusPublished - 1 Jan 2017

Fingerprint

Micelles
RNA
Small Interfering RNA
therapy
delivery
micelles
cancer
Docks
Nucleic acids
nucleic acids
cells
half life
Nucleic Acids
Cations
Tumors
Polymers
vehicles
drugs
tumors
Positive ions

Keywords

  • Active targeting
  • Multidrug resistance
  • Passive targeting
  • Polymeric micelles
  • Proton sponge effect
  • siRNA

ASJC Scopus subject areas

  • Ceramics and Composites
  • Surfaces and Interfaces
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cite this

Recent advances in the design, development, and targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy. / Amjad, Muhammad Wahab; Kesharwani, Prashant; Mohd Amin, Mohd Cairul Iqbal; Iyer, Arun K.

In: Progress in Polymer Science, Vol. 64, 01.01.2017, p. 154-181.

Research output: Contribution to journalReview article

@article{8ab78b07ee0045d39ee3eee4106e45df,
title = "Recent advances in the design, development, and targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy",
abstract = "Small interfering RNA (siRNA) is a relatively novel nucleic acid-based therapy to treat diseases such as cancer. Nevertheless, substantial obstacles to its clinical applications have been reported, such as low cellular uptake, immunogenicity, off-target effects, and instability in physiological environments. The design of appropriate delivery vehicles capable of transporting siRNA to target cells has been pursued. Nanoparticles are extensively studied for the delivery of siRNA. Among the various nanocarriers, polymeric micelles have recently gained strong interest. Polymeric micelles of average nanometer size are straightforward to design and modify. Hydrophilic groups incorporated in the polymeric micelles can extend in vivo half-life of siRNA to ensure adequate accumulation in tumors, be exchanged for cations that electrostatically interact with siRNA, and be coupled to various ligands for cell-specific targeting. The polymeric micelle core provides stability and serves as a loading dock for drugs. In this review, the different types of polymers used, the design and characterization of polymeric micelles for siRNA delivery, and the established polymeric micelle targeting mechanisms are discussed.",
keywords = "Active targeting, Multidrug resistance, Passive targeting, Polymeric micelles, Proton sponge effect, siRNA",
author = "Amjad, {Muhammad Wahab} and Prashant Kesharwani and {Mohd Amin}, {Mohd Cairul Iqbal} and Iyer, {Arun K.}",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.progpolymsci.2016.09.008",
language = "English",
volume = "64",
pages = "154--181",
journal = "Progress in Polymer Science",
issn = "0079-6700",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Recent advances in the design, development, and targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy

AU - Amjad, Muhammad Wahab

AU - Kesharwani, Prashant

AU - Mohd Amin, Mohd Cairul Iqbal

AU - Iyer, Arun K.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Small interfering RNA (siRNA) is a relatively novel nucleic acid-based therapy to treat diseases such as cancer. Nevertheless, substantial obstacles to its clinical applications have been reported, such as low cellular uptake, immunogenicity, off-target effects, and instability in physiological environments. The design of appropriate delivery vehicles capable of transporting siRNA to target cells has been pursued. Nanoparticles are extensively studied for the delivery of siRNA. Among the various nanocarriers, polymeric micelles have recently gained strong interest. Polymeric micelles of average nanometer size are straightforward to design and modify. Hydrophilic groups incorporated in the polymeric micelles can extend in vivo half-life of siRNA to ensure adequate accumulation in tumors, be exchanged for cations that electrostatically interact with siRNA, and be coupled to various ligands for cell-specific targeting. The polymeric micelle core provides stability and serves as a loading dock for drugs. In this review, the different types of polymers used, the design and characterization of polymeric micelles for siRNA delivery, and the established polymeric micelle targeting mechanisms are discussed.

AB - Small interfering RNA (siRNA) is a relatively novel nucleic acid-based therapy to treat diseases such as cancer. Nevertheless, substantial obstacles to its clinical applications have been reported, such as low cellular uptake, immunogenicity, off-target effects, and instability in physiological environments. The design of appropriate delivery vehicles capable of transporting siRNA to target cells has been pursued. Nanoparticles are extensively studied for the delivery of siRNA. Among the various nanocarriers, polymeric micelles have recently gained strong interest. Polymeric micelles of average nanometer size are straightforward to design and modify. Hydrophilic groups incorporated in the polymeric micelles can extend in vivo half-life of siRNA to ensure adequate accumulation in tumors, be exchanged for cations that electrostatically interact with siRNA, and be coupled to various ligands for cell-specific targeting. The polymeric micelle core provides stability and serves as a loading dock for drugs. In this review, the different types of polymers used, the design and characterization of polymeric micelles for siRNA delivery, and the established polymeric micelle targeting mechanisms are discussed.

KW - Active targeting

KW - Multidrug resistance

KW - Passive targeting

KW - Polymeric micelles

KW - Proton sponge effect

KW - siRNA

UR - http://www.scopus.com/inward/record.url?scp=85005995802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85005995802&partnerID=8YFLogxK

U2 - 10.1016/j.progpolymsci.2016.09.008

DO - 10.1016/j.progpolymsci.2016.09.008

M3 - Review article

AN - SCOPUS:85005995802

VL - 64

SP - 154

EP - 181

JO - Progress in Polymer Science

JF - Progress in Polymer Science

SN - 0079-6700

ER -