Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids

Fatin Lyana Azman Shah, Ahmad Bazli Ramzi, Syarul Nataqain Baharum, Normah Mohd Noor, Hoe Han Goh, Thean Chor Leow, Siti Nurbaya Oslan, Suriana Sabri

Research output: Contribution to journalReview article

Abstract

Flavonoids are polyphenols that are important organic chemicals in plants. The health benefits of flavonoids that result in high commercial values make them attractive targets for large-scale production through bioengineering. Strategies such as engineering a flavonoid biosynthetic pathway in microbial hosts provide an alternative way to produce these beneficial compounds. Escherichia coli, Saccharomyces cerevisiae and Streptomyces sp. are among the expression systems used to produce recombinant products, as well as for the production of flavonoid compounds through various bioengineering approaches including clustered regularly interspaced short palindromic repeats (CRISPR)-based genome engineering and genetically encoded biosensors to detect flavonoid biosynthesis. In this study, we review the recent advances in engineering model microbial hosts as being the factory to produce targeted flavonoid compounds.

Original languageEnglish
JournalMolecular Biology Reports
DOIs
Publication statusAccepted/In press - 1 Jan 2019

Fingerprint

Flavonoids
Bioengineering
Clustered Regularly Interspaced Short Palindromic Repeats
Organic Chemicals
Biosynthetic Pathways
Streptomyces
Polyphenols
Biosensing Techniques
Insurance Benefits
Saccharomyces cerevisiae
Genome
Escherichia coli

Keywords

  • Escherichia coli
  • Flavonoid
  • Metabolic engineering
  • Saccharomyces cerevisiae
  • Streptomyces sp

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids. / Shah, Fatin Lyana Azman; Ramzi, Ahmad Bazli; Baharum, Syarul Nataqain; Noor, Normah Mohd; Goh, Hoe Han; Leow, Thean Chor; Oslan, Siti Nurbaya; Sabri, Suriana.

In: Molecular Biology Reports, 01.01.2019.

Research output: Contribution to journalReview article

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