Rapid mold-free manufacturing of microfluidic devices with robust and spatially directed surface modifications

Gaspard Pardon, Farizah Saharil, J. Mikael Karlsson, Omkar Supekar, Carl Fredrik Carlborg, Wouter van der Wijngaart, Tommy Haraldsson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A new and easy-to-use method that allows for mold-free and rapid prototyping of microfluidic devices, comprising channels, access holes, and surface-modified patterns, is presented. The innovative method is based on direct photolithographic patterning of an off-stoichiometry thiol-ene (OSTE) polymer formulation, tailor-made for photolithography, which offers unprecedented spatial resolution and allows for efficient, robust and reliable, room temperature surface modification and glue-free, covalent room temperature bonding. This mold-free process does not require clean room equipment and therefore allows for rapid, i.e., less than one hour, design-fabricate-test cycles, using a material suited for larger-scale production. The excellent photolithographic properties of this new OSTE formulation allow patterning with unprecedented, for thiol-ene polymer systems, resolution in hundreds of micrometers thick layers, 200 μm thick in this work. Moreover, we demonstrated robust, covalent and spatially controlled modification of the microchannel surfaces with an initial contact angle of 76° by patterning hydrophobic/hydrophilic areas with contact angles of 102° and 43°, respectively.

Original languageEnglish
Pages (from-to)773-779
Number of pages7
JournalMicrofluidics and Nanofluidics
Volume17
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

microfluidic devices
Sulfhydryl Compounds
Microfluidics
thiols
Stoichiometry
Contact angle
Surface treatment
manufacturing
Clean rooms
Glues
stoichiometry
Polymers
Rapid prototyping
Photolithography
Microchannels
clean rooms
formulations
rapid prototyping
glues
polymers

Keywords

  • Lab on chip
  • Microfluidics
  • OSTE polymer
  • Photolithography
  • Surface modification

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry

Cite this

Pardon, G., Saharil, F., Karlsson, J. M., Supekar, O., Carlborg, C. F., van der Wijngaart, W., & Haraldsson, T. (2014). Rapid mold-free manufacturing of microfluidic devices with robust and spatially directed surface modifications. Microfluidics and Nanofluidics, 17(4), 773-779. https://doi.org/10.1007/s10404-014-1351-9

Rapid mold-free manufacturing of microfluidic devices with robust and spatially directed surface modifications. / Pardon, Gaspard; Saharil, Farizah; Karlsson, J. Mikael; Supekar, Omkar; Carlborg, Carl Fredrik; van der Wijngaart, Wouter; Haraldsson, Tommy.

In: Microfluidics and Nanofluidics, Vol. 17, No. 4, 2014, p. 773-779.

Research output: Contribution to journalArticle

Pardon, G, Saharil, F, Karlsson, JM, Supekar, O, Carlborg, CF, van der Wijngaart, W & Haraldsson, T 2014, 'Rapid mold-free manufacturing of microfluidic devices with robust and spatially directed surface modifications', Microfluidics and Nanofluidics, vol. 17, no. 4, pp. 773-779. https://doi.org/10.1007/s10404-014-1351-9
Pardon, Gaspard ; Saharil, Farizah ; Karlsson, J. Mikael ; Supekar, Omkar ; Carlborg, Carl Fredrik ; van der Wijngaart, Wouter ; Haraldsson, Tommy. / Rapid mold-free manufacturing of microfluidic devices with robust and spatially directed surface modifications. In: Microfluidics and Nanofluidics. 2014 ; Vol. 17, No. 4. pp. 773-779.
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