Rapid fabrication of OSTE+ microfluidic devices with lithographically defined hydrophobic/ hydrophilic patterns and biocompatible chip sealing

X. Zhou, C. F. Calborg, N. Sandström, A. Haleem, A. Vastesson, F. Saharil, W. Van Der Wijngaart, T. Haraldsson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Here we present an uncomplicated and robust method for rapid prototyping of microfluidic devices featuring: 1) lithographically defined, permanently surface modified hydrophilic and hydrophobic regions with contact angles varying from 18° to 118°, in which all four channel walls are surface modified in a single step using polymer chain grafting; 2) polymer chains grafted from open surfaces before bonding, making this method suitable for batch fabrication; 3) biomolecule-compatible, room temperature, dry, homogeneous chip-sealing, in which native as well as hydrophobic/hydrophilic modified OSTE+ surfaces allow for epoxy-epoxy and thiol-epoxy covalent bonding, hence greatly simplifying alignment and dramatically increasing device yields. We demonstrate the method with a functional microfluidic device. This represents a complete, simplified and robust method for batch-manufacturing compatible prototyping of microfluidic devices with tunable mechanical and surface properties.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages134-136
Number of pages3
Volume1
ISBN (Print)9781632666246
Publication statusPublished - 2013
Externally publishedYes
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg
Duration: 27 Oct 201331 Oct 2013

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CityFreiburg
Period27/10/1331/10/13

Fingerprint

Microfluidics
Fabrication
Polymers
Rapid prototyping
Biomolecules
Sulfhydryl Compounds
Contact angle
Surface properties
Mechanical properties
Temperature

Keywords

  • Dry bonding
  • Hydrophilic
  • Hydrophobic
  • Lithography
  • Microdevice
  • Microfluidics
  • Surface modification
  • Thiol-ene
  • Thiol-ene-epoxy

ASJC Scopus subject areas

  • Bioengineering

Cite this

Zhou, X., Calborg, C. F., Sandström, N., Haleem, A., Vastesson, A., Saharil, F., ... Haraldsson, T. (2013). Rapid fabrication of OSTE+ microfluidic devices with lithographically defined hydrophobic/ hydrophilic patterns and biocompatible chip sealing. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 (Vol. 1, pp. 134-136). Chemical and Biological Microsystems Society.

Rapid fabrication of OSTE+ microfluidic devices with lithographically defined hydrophobic/ hydrophilic patterns and biocompatible chip sealing. / Zhou, X.; Calborg, C. F.; Sandström, N.; Haleem, A.; Vastesson, A.; Saharil, F.; Van Der Wijngaart, W.; Haraldsson, T.

17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Vol. 1 Chemical and Biological Microsystems Society, 2013. p. 134-136.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zhou, X, Calborg, CF, Sandström, N, Haleem, A, Vastesson, A, Saharil, F, Van Der Wijngaart, W & Haraldsson, T 2013, Rapid fabrication of OSTE+ microfluidic devices with lithographically defined hydrophobic/ hydrophilic patterns and biocompatible chip sealing. in 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. vol. 1, Chemical and Biological Microsystems Society, pp. 134-136, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, Freiburg, 27/10/13.
Zhou X, Calborg CF, Sandström N, Haleem A, Vastesson A, Saharil F et al. Rapid fabrication of OSTE+ microfluidic devices with lithographically defined hydrophobic/ hydrophilic patterns and biocompatible chip sealing. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Vol. 1. Chemical and Biological Microsystems Society. 2013. p. 134-136
Zhou, X. ; Calborg, C. F. ; Sandström, N. ; Haleem, A. ; Vastesson, A. ; Saharil, F. ; Van Der Wijngaart, W. ; Haraldsson, T. / Rapid fabrication of OSTE+ microfluidic devices with lithographically defined hydrophobic/ hydrophilic patterns and biocompatible chip sealing. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Vol. 1 Chemical and Biological Microsystems Society, 2013. pp. 134-136
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AU - Saharil, F.

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