Randomized controlled trial of heparin for prevention of blockage of peripherally inserted central catheters in neonates

F. Kamala, N. Y. Boo, Cheah Fook Choe, K. Birinder

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Aim: To determine whether the addition of heparin to total parenteral nutrition (TPN) fluid would prevent blockage of peripherally inserted central catheters (PICCs) in neonates. Methods: This was a randomized, double-blind, controlled study of 66 eligible neonates with PICCs inserted for the administration of TPN. Infants were randomized to receive TPN containing either 1 IU ml-1 of heparin (n = 35) or no heparin (n = 31). Results: There was no significant difference in the incidence of blocked catheters between the two groups of infants (heparin: 14.3%; no-heparin: 22.6%, p = 0.4). Although a higher percentage (62.9%) of infants in the heparin group received a complete course of TPN successfully via PICC than those in the no-heparin group (48.4%), the difference was not statistically significant (p = 0.3). There were no significant differences in the incidence of catheter-related sepsis, hypertriglyceridaemia, hyperbilirubinaemia, coagulopathy or intraventricular haemorrhage between the two groups. Conclusion: Addition of heparin to TPN fluid was not associated with a significant reduction in the incidence of blocked PICCs. However, the sample size of this study was too small to exclude even rather marked differences between the groups.

Original languageEnglish
Pages (from-to)1350-1356
Number of pages7
JournalActa Paediatrica, International Journal of Paediatrics
Volume91
Issue number12
Publication statusPublished - 2002

Fingerprint

Heparin
Catheters
Randomized Controlled Trials
Total Parenteral Nutrition
Newborn Infant
Incidence
Hyperbilirubinemia
Hypertriglyceridemia
Double-Blind Method
Sample Size
Sepsis
Hemorrhage

Keywords

  • Catheter blockage
  • Heparin
  • Peripherally inserted central catheters

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Randomized controlled trial of heparin for prevention of blockage of peripherally inserted central catheters in neonates. / Kamala, F.; Boo, N. Y.; Fook Choe, Cheah; Birinder, K.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 91, No. 12, 2002, p. 1350-1356.

Research output: Contribution to journalArticle

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