Quantitative analysis of sulphated glycosaminoglycans content of Malaysian sea cucumber Stichopus hermanni and Stichopus vastus

Siti Fathiah Masre, George W. Yip, K. N S Sirajudeen, Farid Che Ghazali

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Stichopus hermanni and Stichopus vastus are sea cucumber species from the Stichopodidae family within the coastal waters of Malaysia. The integument of these invertebrates is hypothesised to contain abundant glycosaminoglycans (GAGs). GAGs are divided into non-sulphated and sulphated GAGs. Sulphated GAGs have various chemico-biological functions that are beneficial to humans. This study quantitatively analysed N-, O-sulphated and total sulphated GAG content from three different anatomical regions (integument, internal organs and coelomic fluid) of S. hermanni and S. vastus. The integument revealed the highest content of total, O-and N-sulphated GAGs, followed by the internal organs and the coelomic fluid for both species of sea cucumbers. The percentage division of O-and N-sulphated GAGs suggested that anatomical parts of both species showed higher levels of O-sulphated GAGs compared to N-sulphated GAGs. In conclusion, these findings indicate that the integument body wall of S. hermanni and S. vastus is a rich source of sulphated GAGs.

Original languageEnglish
Pages (from-to)684-689
Number of pages6
JournalNatural Product Research
Volume26
Issue number7
DOIs
Publication statusPublished - 1 Apr 2012

Fingerprint

A73025
Stichopus vastus
Stichopus
Sea Cucumbers
Holothuroidea
glycosaminoglycans
quantitative analysis
Chemical analysis
integument
Glycosaminoglycans
Stichopodidae
Fluids
Malaysia
Invertebrates

Keywords

  • chondroitin sulphate
  • heparan sulphate
  • sea cucumber
  • Stichopodidae
  • sulphated glycosaminoglycans

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Quantitative analysis of sulphated glycosaminoglycans content of Malaysian sea cucumber Stichopus hermanni and Stichopus vastus. / Masre, Siti Fathiah; Yip, George W.; Sirajudeen, K. N S; Ghazali, Farid Che.

In: Natural Product Research, Vol. 26, No. 7, 01.04.2012, p. 684-689.

Research output: Contribution to journalArticle

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