Abstract
Stichopus hermanni and Stichopus vastus are sea cucumber species from the Stichopodidae family within the coastal waters of Malaysia. The integument of these invertebrates is hypothesised to contain abundant glycosaminoglycans (GAGs). GAGs are divided into non-sulphated and sulphated GAGs. Sulphated GAGs have various chemico-biological functions that are beneficial to humans. This study quantitatively analysed N-, O-sulphated and total sulphated GAG content from three different anatomical regions (integument, internal organs and coelomic fluid) of S. hermanni and S. vastus. The integument revealed the highest content of total, O-and N-sulphated GAGs, followed by the internal organs and the coelomic fluid for both species of sea cucumbers. The percentage division of O-and N-sulphated GAGs suggested that anatomical parts of both species showed higher levels of O-sulphated GAGs compared to N-sulphated GAGs. In conclusion, these findings indicate that the integument body wall of S. hermanni and S. vastus is a rich source of sulphated GAGs.
| Original language | English |
|---|---|
| Pages (from-to) | 684-689 |
| Number of pages | 6 |
| Journal | Natural Product Research |
| Volume | 26 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1 Apr 2012 |
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Keywords
- chondroitin sulphate
- heparan sulphate
- sea cucumber
- Stichopodidae
- sulphated glycosaminoglycans
ASJC Scopus subject areas
- Plant Science
- Biochemistry
- Analytical Chemistry
- Organic Chemistry
Cite this
Quantitative analysis of sulphated glycosaminoglycans content of Malaysian sea cucumber Stichopus hermanni and Stichopus vastus. / Masre, Siti Fathiah; Yip, George W.; Sirajudeen, K. N S; Ghazali, Farid Che.
In: Natural Product Research, Vol. 26, No. 7, 01.04.2012, p. 684-689.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Quantitative analysis of sulphated glycosaminoglycans content of Malaysian sea cucumber Stichopus hermanni and Stichopus vastus
AU - Masre, Siti Fathiah
AU - Yip, George W.
AU - Sirajudeen, K. N S
AU - Ghazali, Farid Che
PY - 2012/4/1
Y1 - 2012/4/1
N2 - Stichopus hermanni and Stichopus vastus are sea cucumber species from the Stichopodidae family within the coastal waters of Malaysia. The integument of these invertebrates is hypothesised to contain abundant glycosaminoglycans (GAGs). GAGs are divided into non-sulphated and sulphated GAGs. Sulphated GAGs have various chemico-biological functions that are beneficial to humans. This study quantitatively analysed N-, O-sulphated and total sulphated GAG content from three different anatomical regions (integument, internal organs and coelomic fluid) of S. hermanni and S. vastus. The integument revealed the highest content of total, O-and N-sulphated GAGs, followed by the internal organs and the coelomic fluid for both species of sea cucumbers. The percentage division of O-and N-sulphated GAGs suggested that anatomical parts of both species showed higher levels of O-sulphated GAGs compared to N-sulphated GAGs. In conclusion, these findings indicate that the integument body wall of S. hermanni and S. vastus is a rich source of sulphated GAGs.
AB - Stichopus hermanni and Stichopus vastus are sea cucumber species from the Stichopodidae family within the coastal waters of Malaysia. The integument of these invertebrates is hypothesised to contain abundant glycosaminoglycans (GAGs). GAGs are divided into non-sulphated and sulphated GAGs. Sulphated GAGs have various chemico-biological functions that are beneficial to humans. This study quantitatively analysed N-, O-sulphated and total sulphated GAG content from three different anatomical regions (integument, internal organs and coelomic fluid) of S. hermanni and S. vastus. The integument revealed the highest content of total, O-and N-sulphated GAGs, followed by the internal organs and the coelomic fluid for both species of sea cucumbers. The percentage division of O-and N-sulphated GAGs suggested that anatomical parts of both species showed higher levels of O-sulphated GAGs compared to N-sulphated GAGs. In conclusion, these findings indicate that the integument body wall of S. hermanni and S. vastus is a rich source of sulphated GAGs.
KW - chondroitin sulphate
KW - heparan sulphate
KW - sea cucumber
KW - Stichopodidae
KW - sulphated glycosaminoglycans
UR - http://www.scopus.com/inward/record.url?scp=84860441212&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860441212&partnerID=8YFLogxK
U2 - 10.1080/14786419.2010.545354
DO - 10.1080/14786419.2010.545354
M3 - Article
C2 - 21859370
AN - SCOPUS:84860441212
VL - 26
SP - 684
EP - 689
JO - Natural Product Research
JF - Natural Product Research
SN - 1478-6419
IS - 7
ER -