Quantification of dark adaptation dynamics in retinitis pigmentosa using non-linear regression analysis

Rokiah Omar, Peter Herse

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: Non-linear regression analysis was used to determine dark adaptation indices in people with retinitis pigmentosa and in control subjects. Methods: Dark adaptation data were collected for 13 people with retinitis pigmentosa and 21 controls using the Goldmann-Weekers Dark Adaptometer. Data were analysed using an exponential non-linear regression model and dark adaptation indices derived. The results were compared to age-related values. Results: The mean cone threshold of the group with RP (4.73 ± 0.19 log units) was significantly greater than that found in the control group (3.69 ± 0.12 log units). The rate of cone dark adaptation in the RP group was not significantly different from that of the control group. The α break in the RP group (6.46 ± 0.70 minutes) was delayed when compared to the control group (4.29 ± 0.21 minutes) and the rate of rod dark adaptation in the RP group was slower (10 ± 2 per cent per minute) than that of the control group (15 ± 1 per cent per minute). Conclusions: This study has shown that a relatively simple data analysis can provide a more quantitative and intuitive description of dark adaptation rates in people with retinal disease. This technique will enable more effective use of dark adaptometry as a supplement to objective electrophysiology, when monitoring people with retinitis pigmentosa.

Original languageEnglish
Pages (from-to)386-389
Number of pages4
JournalClinical and Experimental Optometry
Volume87
Issue number6
DOIs
Publication statusPublished - Nov 2004

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Dark Adaptation
Retinitis Pigmentosa
Regression Analysis
Control Groups
Retinal Diseases
Nonlinear Dynamics
Electrophysiology

Keywords

  • Dark adaptation
  • Retinitis pigmentosa

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry

Cite this

Quantification of dark adaptation dynamics in retinitis pigmentosa using non-linear regression analysis. / Omar, Rokiah; Herse, Peter.

In: Clinical and Experimental Optometry, Vol. 87, No. 6, 11.2004, p. 386-389.

Research output: Contribution to journalArticle

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