Qualitative and quantitative assessment of immune cells in oral mucosal lichen planus (OMLP)

Suraya Hani Mohd. Sinon, A. M. Rich, N. A. Firth, G. J. Seymour

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cell mediated immunity is currently thought to be involved in the pathogenesis of oral mucosal lichen planus (OMLP). However, literature reveals there is no large scale data of immunohistochemistry (IHC) study on these immune cell populations. The aim of this study was to assess and compare immune cell surface identification markers CD3, CD4, CD8, CD19 and CD83 between the OMLP (n=40) and non-specific inflammatory lesions (as control group) (n=10) qualitatively and quantitatively. Kruskal-Wallis and Mann Whitney U tests have been used to make comparison between the test and control group, p values of less than 0.05 was considered to be statistically significant. T cell surface markers (CD3+, CD4+ and CD8+), B cells (CD19+) and mature dendritic cells (CD83+) showed intense immunostaining in OMLP tissues with a significantly higher expression of positive cells than in the control group (p<0.05). CD3, CD4 and CD8+ve T cells were the predominant inflammatory cell type in OMLP rather than CD19+ B cells, supporting the role of Th1 cells in the pathogenesis of OMLP. CD83+ mature dendritic cells were present in the least number and were mostly localized to areas where there were aggregates of lymphocyte. There was a positive correlation and direct relationship between T and B lymphocyte subsets whereby as one subset increased, the other follows.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalSains Malaysiana
Volume42
Issue number1
Publication statusPublished - Jan 2013

Fingerprint

Oral Lichen Planus
Dendritic Cells
Control Groups
B-Lymphocytes
B-Lymphocyte Subsets
T-Lymphocytes
Th1 Cells
T-Lymphocyte Subsets
Nonparametric Statistics
Cellular Immunity
Immunohistochemistry
Lymphocytes
Population

Keywords

  • Immune cells
  • Immunohistochemistry (IHC)
  • Oral mucosal lichen planus (OMLP)

ASJC Scopus subject areas

  • General

Cite this

Qualitative and quantitative assessment of immune cells in oral mucosal lichen planus (OMLP). / Mohd. Sinon, Suraya Hani; Rich, A. M.; Firth, N. A.; Seymour, G. J.

In: Sains Malaysiana, Vol. 42, No. 1, 01.2013, p. 65-71.

Research output: Contribution to journalArticle

Mohd. Sinon, Suraya Hani ; Rich, A. M. ; Firth, N. A. ; Seymour, G. J. / Qualitative and quantitative assessment of immune cells in oral mucosal lichen planus (OMLP). In: Sains Malaysiana. 2013 ; Vol. 42, No. 1. pp. 65-71.
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