Pyrazoloquinolines and zolpidem: Effects on hypertonic saline consumption in rehydrating rats

S. J. Cooper, A. Desa

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Male rats were adapted to a 22-hr-daily water-deprivation schedule and to consuming an aversive 2.7% NaCl solution in a 30-min period. Previous reports had shown that benzodiazepines and other anxiolytics stimulate ingestion of hypertonic saline under these conditions; however, two pyrazoloquinolines, CGS 9895 and CGS 9896, failed to do so [Cooper, 1987]. The present experiments were designed to investigate possible antagonist properties of CGS 9895 and CGS 9896 in this model and also to characterize the effects of a newly described pyrazoloquinoline, CGS 17867A, on saline drinking. In addition, a novel sedative-hypnotic, zolpidem, and a benzodiazepine peripheral-type receptor compound, Ro5-4864, were treated. The results indicate that CGS 9895 and CGS 9896 exhibited antagonistic activity in this model, that CGS 17867A increased salt drinking without displaying antagonist activity, and that neither zolpidem nor Ro5-4864 affected drinking responses.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalDrug Development Research
Volume14
Issue number2
Publication statusPublished - 1988
Externally publishedYes

Fingerprint

Drinking
Rats
Benzodiazepines
Water Deprivation
Anti-Anxiety Agents
GABA-A Receptors
Hypnotics and Sedatives
Appointments and Schedules
Salts
Eating
Water
zolpidem
2,5-dihydro-2-(4-methoxyphenyl)-3H-pyrazolo(4,3-c)quinolin-3-one
2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3H)-one
Experiments
CGS 17867A
4'-chlorodiazepam

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Pyrazoloquinolines and zolpidem : Effects on hypertonic saline consumption in rehydrating rats. / Cooper, S. J.; Desa, A.

In: Drug Development Research, Vol. 14, No. 2, 1988, p. 161-168.

Research output: Contribution to journalArticle

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