pS2 expression in infiltrating ductal carcinoma of the breast correlates with oestrogen receptor positivity but not with histological grade and lymph node status

L. M. Looi, Wan Azura Wy Wan Azura, P. L. Cheah, Min Hwei Ng

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This investigation was carried out to gain insight into the prevalence of pS2 expression in invasive ductal breast carcinoma in the Malaysian population and its correlation with oestrogen receptor (ER) protein expression and tumour aggressiveness. Seventy consecutive infiltrating ductal breast carcinomas treated with mastectomy and axillary lymph node clearance were investigated, using the standard avidin-biotin complex immunoperoxidase method with microwave antigen retrieval and commercial monoclonal antibodies (Dako), for expression of pS2 and human ER. This was correlated against histological grade (modified Bloom and Richardson) and the presence of axillary lymph node metastasis of these carcinomas. Four (5.7%) were grade 1, 40 (57.1%) grade 2 and 26 (37.1%) grade 3 tumours. A total of 45 (64%) showed histological evidence of axillary lymph node metastasis. Forty (57%) were ER-positive, while 31 (44%) were pS2-positive. There was a statistically significant correlation between pS2 and ER expressions (X2-test with Yates correction: P<0.005) no correlation between pS2 expression and histological grade (P>0.1) and the presence of lymph node metastasis (P>0.1). Our findings support the views that pS2 may be a co-marker of endocrine responsiveness in invasive breast cancer and that it does not influence breast cancer biology in terms of potential for metastatic spread.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalPathology
Volume33
Issue number3
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Carcinoma, Ductal, Breast
Estrogen Receptors
Lymph Nodes
Neoplasm Metastasis
Breast Neoplasms
Avidin
Mastectomy
Biotin
Microwaves
Neoplasms
Monoclonal Antibodies
Carcinoma
Antigens
Population

Keywords

  • Breast cancer prognosis
  • Estrogen receptor
  • Oestrogen receptor
  • pS2

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

pS2 expression in infiltrating ductal carcinoma of the breast correlates with oestrogen receptor positivity but not with histological grade and lymph node status. / Looi, L. M.; Wy Wan Azura, Wan Azura; Cheah, P. L.; Ng, Min Hwei.

In: Pathology, Vol. 33, No. 3, 2001, p. 283-286.

Research output: Contribution to journalArticle

@article{f822bc42aae24cd786ee632952e845cd,
title = "pS2 expression in infiltrating ductal carcinoma of the breast correlates with oestrogen receptor positivity but not with histological grade and lymph node status",
abstract = "This investigation was carried out to gain insight into the prevalence of pS2 expression in invasive ductal breast carcinoma in the Malaysian population and its correlation with oestrogen receptor (ER) protein expression and tumour aggressiveness. Seventy consecutive infiltrating ductal breast carcinomas treated with mastectomy and axillary lymph node clearance were investigated, using the standard avidin-biotin complex immunoperoxidase method with microwave antigen retrieval and commercial monoclonal antibodies (Dako), for expression of pS2 and human ER. This was correlated against histological grade (modified Bloom and Richardson) and the presence of axillary lymph node metastasis of these carcinomas. Four (5.7{\%}) were grade 1, 40 (57.1{\%}) grade 2 and 26 (37.1{\%}) grade 3 tumours. A total of 45 (64{\%}) showed histological evidence of axillary lymph node metastasis. Forty (57{\%}) were ER-positive, while 31 (44{\%}) were pS2-positive. There was a statistically significant correlation between pS2 and ER expressions (X2-test with Yates correction: P<0.005) no correlation between pS2 expression and histological grade (P>0.1) and the presence of lymph node metastasis (P>0.1). Our findings support the views that pS2 may be a co-marker of endocrine responsiveness in invasive breast cancer and that it does not influence breast cancer biology in terms of potential for metastatic spread.",
keywords = "Breast cancer prognosis, Estrogen receptor, Oestrogen receptor, pS2",
author = "Looi, {L. M.} and {Wy Wan Azura}, {Wan Azura} and Cheah, {P. L.} and Ng, {Min Hwei}",
year = "2001",
language = "English",
volume = "33",
pages = "283--286",
journal = "Pathology",
issn = "0031-3025",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - pS2 expression in infiltrating ductal carcinoma of the breast correlates with oestrogen receptor positivity but not with histological grade and lymph node status

AU - Looi, L. M.

AU - Wy Wan Azura, Wan Azura

AU - Cheah, P. L.

AU - Ng, Min Hwei

PY - 2001

Y1 - 2001

N2 - This investigation was carried out to gain insight into the prevalence of pS2 expression in invasive ductal breast carcinoma in the Malaysian population and its correlation with oestrogen receptor (ER) protein expression and tumour aggressiveness. Seventy consecutive infiltrating ductal breast carcinomas treated with mastectomy and axillary lymph node clearance were investigated, using the standard avidin-biotin complex immunoperoxidase method with microwave antigen retrieval and commercial monoclonal antibodies (Dako), for expression of pS2 and human ER. This was correlated against histological grade (modified Bloom and Richardson) and the presence of axillary lymph node metastasis of these carcinomas. Four (5.7%) were grade 1, 40 (57.1%) grade 2 and 26 (37.1%) grade 3 tumours. A total of 45 (64%) showed histological evidence of axillary lymph node metastasis. Forty (57%) were ER-positive, while 31 (44%) were pS2-positive. There was a statistically significant correlation between pS2 and ER expressions (X2-test with Yates correction: P<0.005) no correlation between pS2 expression and histological grade (P>0.1) and the presence of lymph node metastasis (P>0.1). Our findings support the views that pS2 may be a co-marker of endocrine responsiveness in invasive breast cancer and that it does not influence breast cancer biology in terms of potential for metastatic spread.

AB - This investigation was carried out to gain insight into the prevalence of pS2 expression in invasive ductal breast carcinoma in the Malaysian population and its correlation with oestrogen receptor (ER) protein expression and tumour aggressiveness. Seventy consecutive infiltrating ductal breast carcinomas treated with mastectomy and axillary lymph node clearance were investigated, using the standard avidin-biotin complex immunoperoxidase method with microwave antigen retrieval and commercial monoclonal antibodies (Dako), for expression of pS2 and human ER. This was correlated against histological grade (modified Bloom and Richardson) and the presence of axillary lymph node metastasis of these carcinomas. Four (5.7%) were grade 1, 40 (57.1%) grade 2 and 26 (37.1%) grade 3 tumours. A total of 45 (64%) showed histological evidence of axillary lymph node metastasis. Forty (57%) were ER-positive, while 31 (44%) were pS2-positive. There was a statistically significant correlation between pS2 and ER expressions (X2-test with Yates correction: P<0.005) no correlation between pS2 expression and histological grade (P>0.1) and the presence of lymph node metastasis (P>0.1). Our findings support the views that pS2 may be a co-marker of endocrine responsiveness in invasive breast cancer and that it does not influence breast cancer biology in terms of potential for metastatic spread.

KW - Breast cancer prognosis

KW - Estrogen receptor

KW - Oestrogen receptor

KW - pS2

UR - http://www.scopus.com/inward/record.url?scp=0034907730&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034907730&partnerID=8YFLogxK

M3 - Article

VL - 33

SP - 283

EP - 286

JO - Pathology

JF - Pathology

SN - 0031-3025

IS - 3

ER -