Proteomics in systems biology

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Proteomics is the study of proteins, the workhorses of cells. Proteins can be subjected to various post-translational modifications, making them dynamic to external perturbation. Proteomics can be divided into four areas: sequence, structural, functional and interaction and expression proteomics. These different areas used different instrumentations and have different focuses. For example, sequence and structural proteomics mainly focus on elucidating a particular protein sequence and structure, respectively. Meanwhile, functional and interaction proteomics concentrate on protein function and interaction partners, whereas expression proteomics allows the cataloguing of total proteins in any given samples, hence providing a holistic overview of various proteins in a cell. The application of expression proteomics in cancer and crop research is detailed in this chapter. The general workflow of expression proteomics consisting the use of mass spectrometry instrumentation has also been described, and some examples of proteomics studies are also presented.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages31-49
Number of pages19
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1102
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Systems Biology
Proteomics
Proteins
Cataloging
Workflow
Post Translational Protein Processing
Crops
Mass spectrometry
Mass Spectrometry

Keywords

  • Enzyme
  • Expression proteomics
  • Mass spectrometry
  • Peptide
  • Protein
  • Shotgun proteomics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wan Kamaruddin, W. M. A., & Hassan, M. (2018). Proteomics in systems biology. In Advances in Experimental Medicine and Biology (pp. 31-49). (Advances in Experimental Medicine and Biology; Vol. 1102). Springer New York LLC. https://doi.org/10.1007/978-3-319-98758-3_3

Proteomics in systems biology. / Wan Kamaruddin, Wan Mohd Aizat; Hassan, Maizom.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 31-49 (Advances in Experimental Medicine and Biology; Vol. 1102).

Research output: Chapter in Book/Report/Conference proceedingChapter

Wan Kamaruddin, WMA & Hassan, M 2018, Proteomics in systems biology. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1102, Springer New York LLC, pp. 31-49. https://doi.org/10.1007/978-3-319-98758-3_3
Wan Kamaruddin WMA, Hassan M. Proteomics in systems biology. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2018. p. 31-49. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-98758-3_3
Wan Kamaruddin, Wan Mohd Aizat ; Hassan, Maizom. / Proteomics in systems biology. Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. pp. 31-49 (Advances in Experimental Medicine and Biology).
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