Proteomics as a tool for tapping potential of entomopathogens as microbial insecticides

Nazmi Harith Fadzilah, Idris Abdul-Ghani, Maizom Hassan

Research output: Contribution to journalReview article

Abstract

Biopesticides are collective pest control harnessing the knowledge of the target pest and its natural enemies that minimize the risks of synthetic pesticides. A subset of biopesticides; bioinsecticides, are specifically used in controlling insect pests. Entomopathogens (EPMs) are micro-organisms sought after as subject for bioinsecticide development. However, lack of understanding of EPM mechanism of toxicity and pathogenicity slowed the progress of bioinsecticide development. Proteomics is a useful tool in elucidating the interaction of entomopathogenic fungi, entomopathogenic bacteria, and entomopathogenic virus with their target host. Collectively, proteomics shed light onto insect host response to EPM infection, mechanism of action of EPM’s toxic proteins and secondary metabolites besides characterizing secreted and membrane-bound proteins of EPM that more precisely describe relevant proteins for host recognition and mediating pathogenesis. However, proteomics requires optimized protein extraction methods to maximize the number of proteins for analysis and availability of organism's genome for a more precise protein identification.

Original languageEnglish
Article numbere21520
JournalArchives of Insect Biochemistry and Physiology
Volume100
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

microbial insecticides
entomopathogens
Insecticides
biopesticides
Proteomics
proteomics
Biological Control Agents
Proteins
proteins
Insects
Toxic Actions
Pest Control
entomopathogenic bacteria
Pest control
Pesticides
entomopathogenic fungi
Virulence
Metabolites
Set theory
Fungi

Keywords

  • bioinsecticide
  • biopesticide
  • entomopathogen
  • pest management
  • proteomics

ASJC Scopus subject areas

  • Physiology
  • Biochemistry
  • Insect Science

Cite this

Proteomics as a tool for tapping potential of entomopathogens as microbial insecticides. / Harith Fadzilah, Nazmi; Abdul-Ghani, Idris; Hassan, Maizom.

In: Archives of Insect Biochemistry and Physiology, Vol. 100, No. 1, e21520, 01.01.2019.

Research output: Contribution to journalReview article

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