Protective Role of Natural Products in Cisplatin-Induced Nephrotoxicity

Nurul Raudzah Adib Ridzuan, Norhashima Abd Rashid, Faizah Othman, Siti Balkis Budin, Khin Pa Pa Hlaing @ Farida Hussan, Seong Lin Teoh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cisplatin is a widely used antineoplastic agent for the treatment of metastatic tumors, advanced bladder cancer and many other solid tumors. However, at higher doses, toxicities such as nephrotoxicity may appear. Cisplatin leads to DNA damage and subsequently renal cell death. Besides that, oxidative stress is also implicated as one of the main causes of nephrotoxicity. Several studies showed that numerous natural products: ginseng, curcumin, licorice, honey and pomegranate were able to reduce the oxidative stress by restoring the levels of antioxidant enzymes and also at the same time act as an anti-inflammatory agent. Furthermore, pre-treatment with vitamin supplementation, such as vitamin C, E and riboflavin markedly decreased serum urea and increased the levels of antioxidant enzymes in the kidney even after cisplatin induction in cancer patients. These natural products possess potent antioxidant and anti-inflammatory medicinal properties, and they can be safely used as a supplementary regime or combination therapy against cisplatin-induced nephrotoxicity. The present review focused on the protective role of a few natural products which is widely used in folk medicines in cisplatin-induced nephrotoxicity.

Original languageEnglish
Pages (from-to)1134-1143
Number of pages10
JournalMini reviews in medicinal chemistry
Volume19
Issue number14
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Biological Products
Cisplatin
Antioxidants
Oxidative Stress
Anti-Inflammatory Agents
Punicaceae
Glycyrrhiza
Kidney
Neoplasms
Panax
Curcumin
Honey
Riboflavin
Traditional Medicine
Enzymes
Vitamin E
Urinary Bladder Neoplasms
Vitamins
Antineoplastic Agents
Ascorbic Acid

Keywords

  • Cancer
  • cisplatin
  • kidney
  • natural product
  • nephrotoxicity
  • toxicity.

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Protective Role of Natural Products in Cisplatin-Induced Nephrotoxicity. / Ridzuan, Nurul Raudzah Adib; Rashid, Norhashima Abd; Othman, Faizah; Budin, Siti Balkis; Pa Pa Hlaing @ Farida Hussan, Khin; Teoh, Seong Lin.

In: Mini reviews in medicinal chemistry, Vol. 19, No. 14, 01.01.2019, p. 1134-1143.

Research output: Contribution to journalArticle

Ridzuan, Nurul Raudzah Adib ; Rashid, Norhashima Abd ; Othman, Faizah ; Budin, Siti Balkis ; Pa Pa Hlaing @ Farida Hussan, Khin ; Teoh, Seong Lin. / Protective Role of Natural Products in Cisplatin-Induced Nephrotoxicity. In: Mini reviews in medicinal chemistry. 2019 ; Vol. 19, No. 14. pp. 1134-1143.
@article{25197302b28044cda2c9d1da41c40058,
title = "Protective Role of Natural Products in Cisplatin-Induced Nephrotoxicity",
abstract = "Cisplatin is a widely used antineoplastic agent for the treatment of metastatic tumors, advanced bladder cancer and many other solid tumors. However, at higher doses, toxicities such as nephrotoxicity may appear. Cisplatin leads to DNA damage and subsequently renal cell death. Besides that, oxidative stress is also implicated as one of the main causes of nephrotoxicity. Several studies showed that numerous natural products: ginseng, curcumin, licorice, honey and pomegranate were able to reduce the oxidative stress by restoring the levels of antioxidant enzymes and also at the same time act as an anti-inflammatory agent. Furthermore, pre-treatment with vitamin supplementation, such as vitamin C, E and riboflavin markedly decreased serum urea and increased the levels of antioxidant enzymes in the kidney even after cisplatin induction in cancer patients. These natural products possess potent antioxidant and anti-inflammatory medicinal properties, and they can be safely used as a supplementary regime or combination therapy against cisplatin-induced nephrotoxicity. The present review focused on the protective role of a few natural products which is widely used in folk medicines in cisplatin-induced nephrotoxicity.",
keywords = "Cancer, cisplatin, kidney, natural product, nephrotoxicity, toxicity.",
author = "Ridzuan, {Nurul Raudzah Adib} and Rashid, {Norhashima Abd} and Faizah Othman and Budin, {Siti Balkis} and {Pa Pa Hlaing @ Farida Hussan}, Khin and Teoh, {Seong Lin}",
year = "2019",
month = "1",
day = "1",
doi = "10.2174/1389557519666190320124438",
language = "English",
volume = "19",
pages = "1134--1143",
journal = "Mini-Reviews in Medicinal Chemistry",
issn = "1389-5575",
publisher = "Bentham Science Publishers B.V.",
number = "14",

}

TY - JOUR

T1 - Protective Role of Natural Products in Cisplatin-Induced Nephrotoxicity

AU - Ridzuan, Nurul Raudzah Adib

AU - Rashid, Norhashima Abd

AU - Othman, Faizah

AU - Budin, Siti Balkis

AU - Pa Pa Hlaing @ Farida Hussan, Khin

AU - Teoh, Seong Lin

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Cisplatin is a widely used antineoplastic agent for the treatment of metastatic tumors, advanced bladder cancer and many other solid tumors. However, at higher doses, toxicities such as nephrotoxicity may appear. Cisplatin leads to DNA damage and subsequently renal cell death. Besides that, oxidative stress is also implicated as one of the main causes of nephrotoxicity. Several studies showed that numerous natural products: ginseng, curcumin, licorice, honey and pomegranate were able to reduce the oxidative stress by restoring the levels of antioxidant enzymes and also at the same time act as an anti-inflammatory agent. Furthermore, pre-treatment with vitamin supplementation, such as vitamin C, E and riboflavin markedly decreased serum urea and increased the levels of antioxidant enzymes in the kidney even after cisplatin induction in cancer patients. These natural products possess potent antioxidant and anti-inflammatory medicinal properties, and they can be safely used as a supplementary regime or combination therapy against cisplatin-induced nephrotoxicity. The present review focused on the protective role of a few natural products which is widely used in folk medicines in cisplatin-induced nephrotoxicity.

AB - Cisplatin is a widely used antineoplastic agent for the treatment of metastatic tumors, advanced bladder cancer and many other solid tumors. However, at higher doses, toxicities such as nephrotoxicity may appear. Cisplatin leads to DNA damage and subsequently renal cell death. Besides that, oxidative stress is also implicated as one of the main causes of nephrotoxicity. Several studies showed that numerous natural products: ginseng, curcumin, licorice, honey and pomegranate were able to reduce the oxidative stress by restoring the levels of antioxidant enzymes and also at the same time act as an anti-inflammatory agent. Furthermore, pre-treatment with vitamin supplementation, such as vitamin C, E and riboflavin markedly decreased serum urea and increased the levels of antioxidant enzymes in the kidney even after cisplatin induction in cancer patients. These natural products possess potent antioxidant and anti-inflammatory medicinal properties, and they can be safely used as a supplementary regime or combination therapy against cisplatin-induced nephrotoxicity. The present review focused on the protective role of a few natural products which is widely used in folk medicines in cisplatin-induced nephrotoxicity.

KW - Cancer

KW - cisplatin

KW - kidney

KW - natural product

KW - nephrotoxicity

KW - toxicity.

UR - http://www.scopus.com/inward/record.url?scp=85070476041&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070476041&partnerID=8YFLogxK

U2 - 10.2174/1389557519666190320124438

DO - 10.2174/1389557519666190320124438

M3 - Article

C2 - 30894108

AN - SCOPUS:85070476041

VL - 19

SP - 1134

EP - 1143

JO - Mini-Reviews in Medicinal Chemistry

JF - Mini-Reviews in Medicinal Chemistry

SN - 1389-5575

IS - 14

ER -