Abstract
Osteoporosis is a serious health problem affecting more than 200 million elderly people worldwide. The early symptoms of this disease are hardly detectable. It causes progressive bone loss, which ultimately renders the patients susceptible to fractures. Osteoporosis must be prevented because the associated fragility fractures result in high morbidity, mortality, and healthcare costs. Many plants used in herbal medicine contain bioactive compounds possessing skeletal protective effects. This paper explores the anti-osteoporotic properties of selected herbal plants, including their actions on osteoblasts (bone forming cells), osteoclasts (bone resorbing cells), and bone remodelling. Some of the herbal plant families included in this review are Berberidaceae, Fabaceae, Arecaceae, Labiatae, Simaroubaceaea, and Myrsinaceae. Their active constituents, mechanisms of action, and pharmaceutical applications were discussed. The literature shows that very few herbal plants have undergone human clinical trials to evaluate their pharmacological effects on bone to date. Therefore, more intensive research should be performed on these plants to validate their anti-osteoporotic properties so that they can complement the currently available conventional drugs in the battle against osteoporosis.
| Language | English |
|---|---|
| Article number | 963 |
| Journal | International Journal of Environmental Research and Public Health |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| State | Published - 11 May 2018 |
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Keywords
- Bone remodelling
- Complementary therapies
- Herbal medicine
- Osteoblast
- Osteoclast
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
Cite this
Protective effects of selected botanical agents on bone. / Jolly, James Jam; Chin, Kok Yong; Alias, Ekram; Chua, Kien Hui; Soelaiman, Ima Nirwana.
In: International Journal of Environmental Research and Public Health, Vol. 15, No. 5, 963, 11.05.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Protective effects of selected botanical agents on bone
AU - Jolly,James Jam
AU - Chin,Kok Yong
AU - Alias,Ekram
AU - Chua,Kien Hui
AU - Soelaiman,Ima Nirwana
PY - 2018/5/11
Y1 - 2018/5/11
N2 - Osteoporosis is a serious health problem affecting more than 200 million elderly people worldwide. The early symptoms of this disease are hardly detectable. It causes progressive bone loss, which ultimately renders the patients susceptible to fractures. Osteoporosis must be prevented because the associated fragility fractures result in high morbidity, mortality, and healthcare costs. Many plants used in herbal medicine contain bioactive compounds possessing skeletal protective effects. This paper explores the anti-osteoporotic properties of selected herbal plants, including their actions on osteoblasts (bone forming cells), osteoclasts (bone resorbing cells), and bone remodelling. Some of the herbal plant families included in this review are Berberidaceae, Fabaceae, Arecaceae, Labiatae, Simaroubaceaea, and Myrsinaceae. Their active constituents, mechanisms of action, and pharmaceutical applications were discussed. The literature shows that very few herbal plants have undergone human clinical trials to evaluate their pharmacological effects on bone to date. Therefore, more intensive research should be performed on these plants to validate their anti-osteoporotic properties so that they can complement the currently available conventional drugs in the battle against osteoporosis.
AB - Osteoporosis is a serious health problem affecting more than 200 million elderly people worldwide. The early symptoms of this disease are hardly detectable. It causes progressive bone loss, which ultimately renders the patients susceptible to fractures. Osteoporosis must be prevented because the associated fragility fractures result in high morbidity, mortality, and healthcare costs. Many plants used in herbal medicine contain bioactive compounds possessing skeletal protective effects. This paper explores the anti-osteoporotic properties of selected herbal plants, including their actions on osteoblasts (bone forming cells), osteoclasts (bone resorbing cells), and bone remodelling. Some of the herbal plant families included in this review are Berberidaceae, Fabaceae, Arecaceae, Labiatae, Simaroubaceaea, and Myrsinaceae. Their active constituents, mechanisms of action, and pharmaceutical applications were discussed. The literature shows that very few herbal plants have undergone human clinical trials to evaluate their pharmacological effects on bone to date. Therefore, more intensive research should be performed on these plants to validate their anti-osteoporotic properties so that they can complement the currently available conventional drugs in the battle against osteoporosis.
KW - Bone remodelling
KW - Complementary therapies
KW - Herbal medicine
KW - Osteoblast
KW - Osteoclast
UR - http://www.scopus.com/inward/record.url?scp=85046854782&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046854782&partnerID=8YFLogxK
U2 - 10.3390/ijerph15050963
DO - 10.3390/ijerph15050963
M3 - Review article
VL - 15
JO - International Journal of Environmental Research and Public Health
T2 - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 5
M1 - 963
ER -