Protection by tocotrienols against hypercholesterolaemia and atheroma

M. K. Teoh, J. M K Chong, Jamaludin Mohamed, K. S. Phang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Antioxidants such as tocotrienols may protect against atherosclerosis since tissue injury from free radicals is a final common pathway of damage in arterial disease. In this study, the effects of tocotrienols on serum cholesterol, lipid peroxides, and aorta atheroma were assessed in rabbits fed an atherogenic diet for 12 weeks. Tocotrienols were more effective than tocopherols in preventing increases in serum LDL (p = 0.03) and total cholesterol (p = 0.008) levels in the cholesterol-fed rabbits. Elevation of serum lipid peroxides was effectively suppressed by tocotrienols (p = 0.01). Both tocopherols and tocotrienols offered significant protection against atheroma in the rabbit aorta, but tocotrienols had a stronger hypolipidaemic effect.

Original languageEnglish
Pages (from-to)255-262
Number of pages8
JournalMedical Journal of Malaysia
Volume49
Issue number3
Publication statusPublished - 1994

Fingerprint

Tocotrienols
Atherosclerotic Plaques
Hypercholesterolemia
Tocopherols
Lipid Peroxides
Cholesterol
Rabbits
Aorta
Serum
Atherogenic Diet
Free Radicals
Atherosclerosis
Antioxidants
Wounds and Injuries

Keywords

  • antioxidants
  • atheroma
  • hypercholesterolaemia
  • tocotrienols
  • vitamin E

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Teoh, M. K., Chong, J. M. K., Mohamed, J., & Phang, K. S. (1994). Protection by tocotrienols against hypercholesterolaemia and atheroma. Medical Journal of Malaysia, 49(3), 255-262.

Protection by tocotrienols against hypercholesterolaemia and atheroma. / Teoh, M. K.; Chong, J. M K; Mohamed, Jamaludin; Phang, K. S.

In: Medical Journal of Malaysia, Vol. 49, No. 3, 1994, p. 255-262.

Research output: Contribution to journalArticle

Teoh, MK, Chong, JMK, Mohamed, J & Phang, KS 1994, 'Protection by tocotrienols against hypercholesterolaemia and atheroma', Medical Journal of Malaysia, vol. 49, no. 3, pp. 255-262.
Teoh, M. K. ; Chong, J. M K ; Mohamed, Jamaludin ; Phang, K. S. / Protection by tocotrienols against hypercholesterolaemia and atheroma. In: Medical Journal of Malaysia. 1994 ; Vol. 49, No. 3. pp. 255-262.
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