Prostate cancer and bone metastases

The underlying mechanisms

Sok Kuan Wong, Nur Vaizura Mohamad, Tijjani Rabiu Giaze, Chin Kok Yong, Norazlina Mohamed, Ima Nirwana Soelaiman

Research output: Contribution to journalReview article

Abstract

Patients with advanced prostate cancer often develop bone metastases, leading to bone pain, skeletal fracture, and increased mortality. Bone provides a hospitable microenvironment to tumor cells. The disease manifestation is driven by the interaction between invading tumor cells, bone-forming osteoblasts, and bone-resorbing osteoclasts. The increased level of osteoclast-activating factor (parathyroid hormone-related peptide, PTHrP) is believed to induce bone resorption by upregulating receptor activator of nuclear factor-kappa B ligand (RANKL) and the release of various growth factors into the bone microenvironment to enhance cancer cell growth. However, the underlying molecular mechanisms remain poorly understood. This review outlines the possible molecular mechanisms involved in governing bone metastases driven by prostate cancer, which further provide the basis in searching for new molecular targets for the development of potential therapy.

Original languageEnglish
Article number2587
JournalInternational journal of molecular sciences
Volume20
Issue number10
DOIs
Publication statusPublished - 2 May 2019

Fingerprint

Bone Neoplasms
metastasis
bones
Prostatic Neoplasms
Bone
cancer
Neoplasm Metastasis
Bone and Bones
Tumors
tumors
RANK Ligand
Parathyroid Hormone-Related Protein
Cells
Tumor Microenvironment
osteoblasts
Osteoclasts
Bone Resorption
pain
hormones
Osteoblasts

Keywords

  • Estrogen
  • Hormone
  • Inflammation
  • Osteoprotegerin

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Prostate cancer and bone metastases : The underlying mechanisms. / Wong, Sok Kuan; Mohamad, Nur Vaizura; Giaze, Tijjani Rabiu; Kok Yong, Chin; Mohamed, Norazlina; Soelaiman, Ima Nirwana.

In: International journal of molecular sciences, Vol. 20, No. 10, 2587, 02.05.2019.

Research output: Contribution to journalReview article

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