Prospective advances in circular RNA investigation

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

circRNAs have emerged as one of the key regulators in many cellular mechanisms and pathogenesis of diseases. However, with the limited knowledge and current technologies for circRNA investigations, there are several challenges that need to be addressed for. These include challenges in understanding the regulation of circRNA biogenesis, experimental designs, and sample preparations to characterize the circRNAs in diseases as well as the bioinformatics pipelines and algorithms. In this chapter, we discussed the above challenges and possible strategies to overcome those limitations. We also addressed the differences between the existing applications and technologies to study the circRNAs in diseases. By addressing these challenges, further understanding of circRNAs roles and regulations as well as the discovery of novel circRNAs could be achieved.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages357-370
Number of pages14
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1087
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Technology
Bioinformatics
Computational Biology
Design of experiments
Research Design
Pipelines
circular RNA

Keywords

  • Challenges
  • circRNA
  • Future directions
  • Identification and analysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sulaiman, S. A., Abdul Murad, N. A., Mohamad Hanif, E. A., Abu, N., & A. Jamal, A. R. (2018). Prospective advances in circular RNA investigation. In Advances in Experimental Medicine and Biology (pp. 357-370). (Advances in Experimental Medicine and Biology; Vol. 1087). Springer New York LLC. https://doi.org/10.1007/978-981-13-1426-1_28

Prospective advances in circular RNA investigation. / Sulaiman, Siti Aishah; Abdul Murad, Nor Azian; Mohamad Hanif, Ezanee Azlina; Abu, Nadiah; A. Jamal, A. Rahman.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 357-370 (Advances in Experimental Medicine and Biology; Vol. 1087).

Research output: Chapter in Book/Report/Conference proceedingChapter

Sulaiman, SA, Abdul Murad, NA, Mohamad Hanif, EA, Abu, N & A. Jamal, AR 2018, Prospective advances in circular RNA investigation. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1087, Springer New York LLC, pp. 357-370. https://doi.org/10.1007/978-981-13-1426-1_28
Sulaiman SA, Abdul Murad NA, Mohamad Hanif EA, Abu N, A. Jamal AR. Prospective advances in circular RNA investigation. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2018. p. 357-370. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-981-13-1426-1_28
Sulaiman, Siti Aishah ; Abdul Murad, Nor Azian ; Mohamad Hanif, Ezanee Azlina ; Abu, Nadiah ; A. Jamal, A. Rahman. / Prospective advances in circular RNA investigation. Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. pp. 357-370 (Advances in Experimental Medicine and Biology).
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