Prophylactic activity of chitosan against Plasmodium berghei infections in BALB/c mice

M. Yun Yuh, Kalaivani K. Nadarajah, B. A H Zainal-Abidin

Research output: Contribution to journalArticle

Abstract

The prophylactic effect of crustacean chitosan (CC) against malarial infection was examined in BALB/c mice. CC dissolved in 0.5% acetic acid at different concentrations was given either intraperitoneally (i.p.) or orally from day 0 to day 5. Mice which received 0.5% acetic acid were used as the negative control whereas mice treated with chloroquine diphosphate were served as the positive control. All mice were infected with parasitized red blood cells on day 4. Our results showed that CC treatment, either administered intraperitoneally or orally, possessed prophylactic effects on blood induced infection of P. berghei. All CC-treated mice exhibited longer life-span when compared to control mice received only vehicle. However, CC treatment intraperitoneally gave stronger protection where a dosage at 250 mg/kg showed significant parasite suppression as well as longer survival time of the infected mice. CC treatment through i.p. route also caused significantly higher neutrophil counts in the peripheral blood. We suggest that the activation of neutrophils in peripheral blood through prophylactic activity of CC may play a crucial role in the antimalarial activity of the host.

Original languageEnglish
Pages (from-to)377-381
Number of pages5
JournalBiosciences Biotechnology Research Asia
Volume4
Issue number2
Publication statusPublished - Dec 2007

Fingerprint

Plasmodium berghei
Chitosan
chitosan
Malaria
crustacean
Crustacea
mice
infection
blood
Acetic Acid
acetic acid
neutrophils
chloroquine
Neutrophil Activation
antimalarials
Antimalarials
Infection
parasite
Parasites
Neutrophils

Keywords

  • BALB/c mice
  • Chitosan
  • Plasmodium berghei
  • Prophylactic activity

ASJC Scopus subject areas

  • Biotechnology
  • Ecology, Evolution, Behavior and Systematics
  • Drug Discovery

Cite this

Prophylactic activity of chitosan against Plasmodium berghei infections in BALB/c mice. / Yun Yuh, M.; K. Nadarajah, Kalaivani; Zainal-Abidin, B. A H.

In: Biosciences Biotechnology Research Asia, Vol. 4, No. 2, 12.2007, p. 377-381.

Research output: Contribution to journalArticle

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